Integration of high-throughput reporter assays identify a critical enhancer of the Ikzf1 gene

The Ikzf1 locus encodes the lymphoid specific transcription factor Ikaros, which plays an essential role in both T and B cell differentiation, while deregulation or mutation of IKZF1/Ikzf1 is involved in leukemia. Tissue-specific and cell identity genes are usually associated with clusters of enhanc...

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Detalles Bibliográficos
Autores principales: Alomairi, Jaafar, Molitor, Anne M., Sadouni, Nori, Hussain, Saadat, Torres, Magali, Saadi, Wiam, Dao, Lan T. M., Charbonnier, Guillaume, Santiago-Algarra, David, Andrau, Jean Christophe, Puthier, Denis, Sexton, Tom, Spicuglia, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250416/
https://www.ncbi.nlm.nih.gov/pubmed/32453736
http://dx.doi.org/10.1371/journal.pone.0233191

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