Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction during myocardial ischemia

The heart is critically dependent on mitochondrial respiration for energy supply. Ischemia decreases oxygen availability, with catastrophic consequences for cellular energy systems. After a few minutes of ischemia, the mitochondrial respiratory chain halts, ATP levels drop and ion gradients across c...

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Detalles Bibliográficos
Autores principales: Sánchez, Gina, Chalmers, Stefanie, Ahumada, Xavier, Montecinos, Luis, Olmedo, Ivonne, Eisner, Veronica, Riveros, Ana, Kogan, Marcelo J., Lavandero, Sergio, Pedrozo, Zully, Donoso, Paulina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250417/
https://www.ncbi.nlm.nih.gov/pubmed/32453773
http://dx.doi.org/10.1371/journal.pone.0233591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250417/
https://www.ncbi.nlm.nih.gov/pubmed/32453773
http://dx.doi.org/10.1371/journal.pone.0233591

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