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Detection of Coxiella burnetii and equine herpesvirus 1, but not Leptospira spp. or Toxoplasma gondii, in cases of equine abortion in Australia - a 25 year retrospective study

Equine abortion is a cause of severe economic loss to the equine industry. Equine herpesvirus 1 is considered a primary cause of infectious abortion in horses, however other infectious agents can also cause abortion. Abortions due to zoonotic pathogens have implications for both human and animal hea...

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Autores principales: Akter, Rumana, Legione, Alistair, Sansom, Fiona M., El-Hage, Charles M., Hartley, Carol A., Gilkerson, James R., Devlin, Joanne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250447/
https://www.ncbi.nlm.nih.gov/pubmed/32453753
http://dx.doi.org/10.1371/journal.pone.0233100
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author Akter, Rumana
Legione, Alistair
Sansom, Fiona M.
El-Hage, Charles M.
Hartley, Carol A.
Gilkerson, James R.
Devlin, Joanne M.
author_facet Akter, Rumana
Legione, Alistair
Sansom, Fiona M.
El-Hage, Charles M.
Hartley, Carol A.
Gilkerson, James R.
Devlin, Joanne M.
author_sort Akter, Rumana
collection PubMed
description Equine abortion is a cause of severe economic loss to the equine industry. Equine herpesvirus 1 is considered a primary cause of infectious abortion in horses, however other infectious agents can also cause abortion. Abortions due to zoonotic pathogens have implications for both human and animal health. We determined the prevalence of Coxiella burnetii, Leptospira spp. and Toxoplasma gondii in 600 aborted equine foetal tissues that were submitted to our diagnostic laboratories at the University of Melbourne from 1994 to 2019. Using qPCR we found that the prevalence of C. burnetii was 4%. The highest annual incidence of C. burnetii was observed between 1997–2003 and 2016–2018. The prevalence of C. burnetii in Victoria and New South Wales was 3% and 6% respectively. All the samples tested negative for Leptospira spp. and Toxoplasma gondii DNA. Equine herpesvirus 1 DNA was detected at a prevalence of 3%. This study has provided evidence for the presence of C. burnetii in equine aborted foetal tissues in Australia, but the role of C. burnetii as potential cause of abortion in Australia requires further investigation. C. burnetii is a zoonotic disease agent that causes the disease ‘Q fever’ in humans. We recommend that appropriate protective measures should be considered when handling material associated with equine abortions to reduce the risk of becoming infected with C. burnetii.
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spelling pubmed-72504472020-06-08 Detection of Coxiella burnetii and equine herpesvirus 1, but not Leptospira spp. or Toxoplasma gondii, in cases of equine abortion in Australia - a 25 year retrospective study Akter, Rumana Legione, Alistair Sansom, Fiona M. El-Hage, Charles M. Hartley, Carol A. Gilkerson, James R. Devlin, Joanne M. PLoS One Research Article Equine abortion is a cause of severe economic loss to the equine industry. Equine herpesvirus 1 is considered a primary cause of infectious abortion in horses, however other infectious agents can also cause abortion. Abortions due to zoonotic pathogens have implications for both human and animal health. We determined the prevalence of Coxiella burnetii, Leptospira spp. and Toxoplasma gondii in 600 aborted equine foetal tissues that were submitted to our diagnostic laboratories at the University of Melbourne from 1994 to 2019. Using qPCR we found that the prevalence of C. burnetii was 4%. The highest annual incidence of C. burnetii was observed between 1997–2003 and 2016–2018. The prevalence of C. burnetii in Victoria and New South Wales was 3% and 6% respectively. All the samples tested negative for Leptospira spp. and Toxoplasma gondii DNA. Equine herpesvirus 1 DNA was detected at a prevalence of 3%. This study has provided evidence for the presence of C. burnetii in equine aborted foetal tissues in Australia, but the role of C. burnetii as potential cause of abortion in Australia requires further investigation. C. burnetii is a zoonotic disease agent that causes the disease ‘Q fever’ in humans. We recommend that appropriate protective measures should be considered when handling material associated with equine abortions to reduce the risk of becoming infected with C. burnetii. Public Library of Science 2020-05-26 /pmc/articles/PMC7250447/ /pubmed/32453753 http://dx.doi.org/10.1371/journal.pone.0233100 Text en © 2020 Akter et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Akter, Rumana
Legione, Alistair
Sansom, Fiona M.
El-Hage, Charles M.
Hartley, Carol A.
Gilkerson, James R.
Devlin, Joanne M.
Detection of Coxiella burnetii and equine herpesvirus 1, but not Leptospira spp. or Toxoplasma gondii, in cases of equine abortion in Australia - a 25 year retrospective study
title Detection of Coxiella burnetii and equine herpesvirus 1, but not Leptospira spp. or Toxoplasma gondii, in cases of equine abortion in Australia - a 25 year retrospective study
title_full Detection of Coxiella burnetii and equine herpesvirus 1, but not Leptospira spp. or Toxoplasma gondii, in cases of equine abortion in Australia - a 25 year retrospective study
title_fullStr Detection of Coxiella burnetii and equine herpesvirus 1, but not Leptospira spp. or Toxoplasma gondii, in cases of equine abortion in Australia - a 25 year retrospective study
title_full_unstemmed Detection of Coxiella burnetii and equine herpesvirus 1, but not Leptospira spp. or Toxoplasma gondii, in cases of equine abortion in Australia - a 25 year retrospective study
title_short Detection of Coxiella burnetii and equine herpesvirus 1, but not Leptospira spp. or Toxoplasma gondii, in cases of equine abortion in Australia - a 25 year retrospective study
title_sort detection of coxiella burnetii and equine herpesvirus 1, but not leptospira spp. or toxoplasma gondii, in cases of equine abortion in australia - a 25 year retrospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250447/
https://www.ncbi.nlm.nih.gov/pubmed/32453753
http://dx.doi.org/10.1371/journal.pone.0233100
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