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SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst

Klebsiella pneumoniae is a respiratory, blood, liver, and bladder pathogen of significant clinical concern. We show that the adaptor protein, SKAP2, is required for protection against K. pneumoniae (ATCC 43816) pulmonary infections. Skap2-/- mice had 100-fold higher bacterial burden when compared to...

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Detalles Bibliográficos
Autores principales:	Nguyen, Giang T, Shaban, Lamyaa, Mack, Matthias, Swanson, Kenneth D, Bunnell, Stephen C, Sykes, David B, Mecsas, Joan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250567/ https://www.ncbi.nlm.nih.gov/pubmed/32352382 http://dx.doi.org/10.7554/eLife.56656

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