Improving the efficiency of precise genome editing with site-specific Cas9-oligonucleotide conjugates

Site-specific chemical conjugation of proteins can enhance their therapeutic and diagnostic utility but has seldom been applied to CRISPR-Cas9, which is a rapidly growing field with great therapeutic potential. The low efficiency of homology-directed repair remains a major hurdle in CRISPR-Cas9–medi...

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Detalles Bibliográficos
Autores principales: Ling, Xinyu, Xie, Bingteng, Gao, Xiaoqin, Chang, Liying, Zheng, Wei, Chen, Heqi, Huang, Yujia, Tan, Linzhi, Li, Mo, Liu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250679/
https://www.ncbi.nlm.nih.gov/pubmed/32494588
http://dx.doi.org/10.1126/sciadv.aaz0051

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