Cargando…

SIRT3 and GCN5L regulation of NADP+- and NADPH-driven reactions of mitochondrial isocitrate dehydrogenase IDH2

Wild type mitochondrial isocitrate dehydrogenase (IDH2) was previously reported to produce oncometabolite 2-hydroxyglutarate (2HG). Besides, mitochondrial deacetylase SIRT3 has been shown to regulate the oxidative function of IDH2. However, regulation of 2HG formation by SIRT3-mediated deacetylation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smolková, Katarína, Špačková, Jitka, Gotvaldová, Klára, Dvořák, Aleš, Křenková, Alena, Hubálek, Martin, Holendová, Blanka, Vítek, Libor, Ježek, Petr
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250847/ https://www.ncbi.nlm.nih.gov/pubmed/32457458 http://dx.doi.org/10.1038/s41598-020-65351-z

Ejemplares similares

Biochemical Background in Mitochondria Affects 2HG Production by IDH2 and ADHFE1 in Breast Carcinoma
por: Špačková, Jitka, et al.
Publicado: (2021)

Mitochondrial Superoxide Production Decreases on Glucose-Stimulated Insulin Secretion in Pancreatic β Cells Due to Decreasing Mitochondrial Matrix NADH/NAD(+) Ratio
por: Plecitá-Hlavatá, Lydie, et al.
Publicado: (2020)

The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells
por: Smolková, Katarína, et al.
Publicado: (2012)

Antioxidant Role and Cardiolipin Remodeling by Redox-Activated Mitochondrial Ca(2+)-Independent Phospholipase A(2)γ in the Brain
por: Průchová, Pavla, et al.
Publicado: (2022)

Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP(+)-dependent isocitrate dehydrogenase (IDH)
por: Yang, Jinsung, et al.
Publicado: (2017)

Purification and Characterization of Cytoplasmic NADP(+)-Isocitrate Dehydrogenase, and Amplification of the Nadp(+)-IDH Gene from the Wing-Dimorphic Sand Field Cricket, Gryllus firmus
por: Zera, Anthony J., et al.
Publicado: (2011)

NADP(+)-dependent cytosolic isocitrate dehydrogenase provides NADPH in the presence of cadmium due to the moderate chelating effect of glutathione
por: Cho, Hyo Je, et al.
Publicado: (2018)

Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio
por: Itsumi, M, et al.
Publicado: (2015)

Functional relevance of dynamic properties of Dimeric NADP-dependent Isocitrate Dehydrogenases
por: Vinekar, Rithvik, et al.
Publicado: (2012)

Apollo-NADP(+) reveals in vivo adaptation of NADPH/NADP(+) metabolism in electrically activated pancreatic β cells
por: Bui, Cindy V., et al.
Publicado: (2023)

The metabolites NADP(+) and NADPH are the targets of the circadian protein Nocturnin (Curled)
por: Estrella, Michael A., et al.
Publicado: (2019)

The prognostic IDH1(R132) mutation is associated with reduced NADP(+)-dependent IDH activity in glioblastoma
por: Bleeker, Fonnet E., et al.
Publicado: (2010)

A genetically encoded tool for manipulation of NADP(+)/NADPH in living cells
por: Cracan, Valentin, et al.
Publicado: (2017)

SREBP modulates the NADP(+)/NADPH cycle to control night sleep in Drosophila
por: Mariano, Vittoria, et al.
Publicado: (2023)

Structural and Functional analysis of Staphylococcus aureus NADP-dependent IDH and its comparison with Bacterial and Human NADPdependent IDH
por: Prasad, Uppu Venkateswara, et al.
Publicado: (2014)

Redox Signaling from Mitochondria: Signal Propagation and Its Targets
por: Ježek, Petr, et al.
Publicado: (2020)

Deficiency of a peroxisomal NADP-isocitrate dehydrogenase leads to dwarf plant and defect seed in upland cotton
por: Cao, Yuefen, et al.
Publicado: (2022)

Isocitrate Dehydrogenase IDH1 and IDH2 Mutations in Human Cancer: Prognostic Implications for Gliomas
por: Murugan, A. K., et al.
Publicado: (2022)

The NADP(+)-dependent IDH1 mutation and its relevance for glioblastoma patient survival
por: Van Noorden, Cornelis JF
Publicado: (2014)

Targeting Apollo-NADP(+) to Image NADPH Generation in Pancreatic Beta-Cell Organelles
por: Chang, Huntley H., et al.
Publicado: (2022)

Mismatch repair protein mutations in isocitrate dehydrogenase (IDH)-mutant astrocytoma and IDH-wild-type glioblastoma
por: Richardson, Timothy E, et al.
Publicado: (2023)

2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP(+)-Dependent Isocitrate Dehydrogenase Mutations
por: Jin, Genglin, et al.
Publicado: (2011)

Enhancement of UVB radiation-mediated apoptosis by knockdown of cytosolic NADP(+)-dependent isocitrate dehydrogenase in HaCaT cells
por: Lee, Su Jeong, et al.
Publicado: (2014)

Liposomes modified with cardiolipin can act as a platform to regulate the potential flux of NADP(+)-dependent isocitrate dehydrogenase
por: Suga, Keishi, et al.
Publicado: (2015)

Mitochondrial NADP(+)-dependent isocitrate dehydrogenase deficiency increases cisplatin-induced oxidative damage in the kidney tubule cells
por: Kong, Min Jung, et al.
Publicado: (2018)

Crystal Structures of the Putative Isocitrate Dehydrogenase from Sulfolobus tokodaii Strain 7 in the Apo and NADP(+)-Bound Forms
por: Kondo, Hisanori, et al.
Publicado: (2018)

Characterization of NAD(+)/NADP(+)-Specific Isocitrate Dehydrogenases From Oleaginous Fungus Mortierella alpina Involved in Lipid Accumulation
por: Tang, Xin, et al.
Publicado: (2021)

Biochemical and Phylogenetic Characterization of a Novel NADP(+)-Specific Isocitrate Dehydrogenase From the Marine Microalga Phaeodactylum tricornutum
por: Huang, Shiping, et al.
Publicado: (2021)

Mutated Isocitrate Dehydrogenase (mIDH) as Target for PET Imaging in Gliomas
por: Neumaier, Felix, et al.
Publicado: (2023)

Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox Signaling
por: Ježek, Petr, et al.
Publicado: (2018)

Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity
por: Ježek, Petr, et al.
Publicado: (2018)

Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
por: Garrett, Matthew, et al.
Publicado: (2018)

Expression of CD133 Cancer Stem Cell Marker in IDH-Mutant and IDH-wildtype (Isocitrate Dehydrogenase) Astrocytoma
por: Sabunga, Olivia Desty, et al.
Publicado: (2022)

Deficiency of transcription factor Nkx6.1 does not prevent insulin secretion in INS-1E cells
por: Pavluch, Vojtěch, et al.
Publicado: (2023)

Antioxidant Synergy of Mitochondrial Phospholipase PNPLA8/iPLA2γ with Fatty Acid–Conducting SLC25 Gene Family Transporters
por: Jabůrek, Martin, et al.
Publicado: (2021)

Mitochondrial Cristae Morphology Reflecting Metabolism, Superoxide Formation, Redox Homeostasis, and Pathology
por: Ježek, Petr, et al.
Publicado: (2023)

Isocitrate Dehydrogenase (IDH)1/2 Mutations as Prognostic Markers in Patients With Glioblastomas
por: Chen, Jun-Rui, et al.
Publicado: (2016)

Identification of Isocitrate Dehydrogenase 2 (IDH2) Mutation in Carotid Body Paraganglioma
por: Lang, Fengchao, et al.
Publicado: (2021)

Determination of the Cytosolic NADPH/NADP Ratio in Saccharomyces cerevisiae using Shikimate Dehydrogenase as Sensor Reaction
por: Zhang, Jinrui, et al.
Publicado: (2015)

NADP-Dependent Isocitrate Dehydrogenase from Arabidopsis Roots Contributes in the Mechanism of Defence against the Nitro-Oxidative Stress Induced by Salinity
por: Leterrier, Marina, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_nvdh4gpbj171s3b1raicbhdm9d