Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need

Although sleep is one of the most conserved behaviors, the intracellular mechanism regulating sleep/wakefulness remains unknown. We recently identified a protein kinase, SIK3, as a sleep-regulating molecule. Mice that lack a well-conserved protein kinase A (PKA) phosphorylation site, S551, showed lo...

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Detalles Bibliográficos
Autores principales: Park, Minjeong, Miyoshi, Chika, Fujiyama, Tomoyuki, Kakizaki, Miyo, Ikkyu, Aya, Honda, Takato, Choi, Jinhwan, Asano, Fuyuki, Mizuno, Seiya, Takahashi, Satoru, Yanagisawa, Masashi, Funato, Hiromasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250853/
https://www.ncbi.nlm.nih.gov/pubmed/32457359
http://dx.doi.org/10.1038/s41598-020-65647-0

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