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Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu

Hyperuricemia is a risk factor for cardiovascular metabolic diseases. However, in the very elderly, the relationship between hyperuricemia and the metabolic syndrome (MetS) is not yet clear. This study was aimed to investigate the potential association between hyperuricemia and MetS in community ver...

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Autores principales: Huang, Gang, Xu, Junbo, Zhang, Tingjie, Cai, Lin, Liu, Hanxiong, Yu, Xiuqiong, Wu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250884/
https://www.ncbi.nlm.nih.gov/pubmed/32457306
http://dx.doi.org/10.1038/s41598-020-65605-w
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author Huang, Gang
Xu, Junbo
Zhang, Tingjie
Cai, Lin
Liu, Hanxiong
Yu, Xiuqiong
Wu, Jing
author_facet Huang, Gang
Xu, Junbo
Zhang, Tingjie
Cai, Lin
Liu, Hanxiong
Yu, Xiuqiong
Wu, Jing
author_sort Huang, Gang
collection PubMed
description Hyperuricemia is a risk factor for cardiovascular metabolic diseases. However, in the very elderly, the relationship between hyperuricemia and the metabolic syndrome (MetS) is not yet clear. This study was aimed to investigate the potential association between hyperuricemia and MetS in community very elderly in Chengdu. In this cross-sectional study, 1056 very elderly in the community were enrolled. Serum uric acid (SUA), fast plasma glucose, triglycerides and high–density lipoprotein cholesterol were measured, and then MetS components were calculated. Logistic regression models were used to explore risk factors for MetS in the very elderly. Finally, 1035 participants were included in analysis whose ages ranged between 80 and 100 with a mean age of 83.6 ± 3.4 years. The mean SUA level was 356.2 ± 95.0 µmol/L. The estimated prevalence of MetS in the very elderly was 25.0% vs. 21.6% (international diabetes federation (IDF) criteria vs. Chinese guideline), which was significantly higher for women (IDF criteria:17.3% in men vs 33.6% in women, p < 0.001). Logistic regression has found that participants with hyperuricemia (SUA level > 416 µmol/L in men and > 357 µmol/L in women) had a higher risk (IDF criteria: odds ratio (OR): 2.136, 95% confidence interval(CI): 1.525–2.993, p < 0.001. Chinese guideline: OR: 1.769, 95%CI: 1.249–2.503, p = 0.001) of MetS in very elderly Chinese. MetS is common in the community of very elderly Chinese in Chengdu. Hyperuricemia is associated with MetS in general very elderly and lifestyle changing should also be considered in the very elderly.
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spelling pubmed-72508842020-06-04 Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu Huang, Gang Xu, Junbo Zhang, Tingjie Cai, Lin Liu, Hanxiong Yu, Xiuqiong Wu, Jing Sci Rep Article Hyperuricemia is a risk factor for cardiovascular metabolic diseases. However, in the very elderly, the relationship between hyperuricemia and the metabolic syndrome (MetS) is not yet clear. This study was aimed to investigate the potential association between hyperuricemia and MetS in community very elderly in Chengdu. In this cross-sectional study, 1056 very elderly in the community were enrolled. Serum uric acid (SUA), fast plasma glucose, triglycerides and high–density lipoprotein cholesterol were measured, and then MetS components were calculated. Logistic regression models were used to explore risk factors for MetS in the very elderly. Finally, 1035 participants were included in analysis whose ages ranged between 80 and 100 with a mean age of 83.6 ± 3.4 years. The mean SUA level was 356.2 ± 95.0 µmol/L. The estimated prevalence of MetS in the very elderly was 25.0% vs. 21.6% (international diabetes federation (IDF) criteria vs. Chinese guideline), which was significantly higher for women (IDF criteria:17.3% in men vs 33.6% in women, p < 0.001). Logistic regression has found that participants with hyperuricemia (SUA level > 416 µmol/L in men and > 357 µmol/L in women) had a higher risk (IDF criteria: odds ratio (OR): 2.136, 95% confidence interval(CI): 1.525–2.993, p < 0.001. Chinese guideline: OR: 1.769, 95%CI: 1.249–2.503, p = 0.001) of MetS in very elderly Chinese. MetS is common in the community of very elderly Chinese in Chengdu. Hyperuricemia is associated with MetS in general very elderly and lifestyle changing should also be considered in the very elderly. Nature Publishing Group UK 2020-05-26 /pmc/articles/PMC7250884/ /pubmed/32457306 http://dx.doi.org/10.1038/s41598-020-65605-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Huang, Gang
Xu, Junbo
Zhang, Tingjie
Cai, Lin
Liu, Hanxiong
Yu, Xiuqiong
Wu, Jing
Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu
title Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu
title_full Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu
title_fullStr Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu
title_full_unstemmed Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu
title_short Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu
title_sort hyperuricemia is associated with metabolic syndrome in the community very elderly in chengdu
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250884/
https://www.ncbi.nlm.nih.gov/pubmed/32457306
http://dx.doi.org/10.1038/s41598-020-65605-w
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