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Fine tuning of the unfolded protein response by ISRIB improves neuronal survival in a model of amyotrophic lateral sclerosis

Loss of protein folding homeostasis features many of the most prevalent neurodegenerative disorders. As coping mechanism to folding stress within the endoplasmic reticulum (ER), the unfolded protein response (UPR) comprises a set of signaling mechanisms that initiate a gene expression program to res...

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Detalles Bibliográficos
Autores principales:	Bugallo, Ricardo, Marlin, Elías, Baltanás, Ana, Toledo, Estefanía, Ferrero, Roberto, Vinueza-Gavilanes, Rodrigo, Larrea, Laura, Arrasate, Montserrat, Aragón, Tomás
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250913/ https://www.ncbi.nlm.nih.gov/pubmed/32457286 http://dx.doi.org/10.1038/s41419-020-2601-2

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