The bromodomain containing protein BRD-9 orchestrates RAD51–RAD54 complex formation and regulates homologous recombination-mediated repair

Homologous recombination (HR) is important for error-free DNA double strand break repair and maintenance of genomic stability. However, upregulated HR is also used by cancer cells to promote therapeutic resistance. Therefore, inducing HR deficiency (HRD) is a viable strategy to sensitize HR proficie...

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Detalles Bibliográficos
Autores principales: Zhou, Qin, Huang, Jinzhou, Zhang, Chao, Zhao, Fei, Kim, Wootae, Tu, Xinyi, Zhang, Yong, Nowsheen, Somaira, Zhu, Qian, Deng, Min, Chen, Yuping, Qin, Bo, Luo, Kuntian, Liu, Baohua, Lou, Zhenkun, Mutter, Robert W., Yuan, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251110/
https://www.ncbi.nlm.nih.gov/pubmed/32457312
http://dx.doi.org/10.1038/s41467-020-16443-x

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