Role of Blood Oxygen Saturation During Post-Natal Human Cardiomyocyte Cell Cycle Activities

Blood oxygen saturation (SaO(2)) is one of the most important environmental factors in clinical heart protection. This study used human heart samples and human induced pluripotent stem cell−cardiomyocytes (iPSC-CMs) to assess how SaO(2) affects human CM cell cycle activities. The results showed that...

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Detalles Bibliográficos
Autores principales: Ye, Lincai, Qiu, Lisheng, Feng, Bei, Jiang, Chuan, Huang, Yanhui, Zhang, Haibo, Zhang, Hao, Hong, Haifa, Liu, Jinfen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251192/
https://www.ncbi.nlm.nih.gov/pubmed/32478207
http://dx.doi.org/10.1016/j.jacbts.2020.02.008
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author Ye, Lincai
Qiu, Lisheng
Feng, Bei
Jiang, Chuan
Huang, Yanhui
Zhang, Haibo
Zhang, Hao
Hong, Haifa
Liu, Jinfen
author_facet Ye, Lincai
Qiu, Lisheng
Feng, Bei
Jiang, Chuan
Huang, Yanhui
Zhang, Haibo
Zhang, Hao
Hong, Haifa
Liu, Jinfen
author_sort Ye, Lincai
collection PubMed
description Blood oxygen saturation (SaO(2)) is one of the most important environmental factors in clinical heart protection. This study used human heart samples and human induced pluripotent stem cell−cardiomyocytes (iPSC-CMs) to assess how SaO(2) affects human CM cell cycle activities. The results showed that there were significantly more cell cycle markers in the moderate hypoxia group (SaO(2): 75% to 85%) than in the other 2 groups (SaO(2) <75% or >85%). In iPSC-CMs 15% and 10% oxygen (O(2)) treatment increased cell cycle markers, whereas 5% and rapid change of O(2) decreased the markers. Moderate hypoxia is beneficial to the cell cycle activities of post-natal human CMs.
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spelling pubmed-72511922020-05-29 Role of Blood Oxygen Saturation During Post-Natal Human Cardiomyocyte Cell Cycle Activities Ye, Lincai Qiu, Lisheng Feng, Bei Jiang, Chuan Huang, Yanhui Zhang, Haibo Zhang, Hao Hong, Haifa Liu, Jinfen JACC Basic Transl Sci PRECLINICAL RESEARCH Blood oxygen saturation (SaO(2)) is one of the most important environmental factors in clinical heart protection. This study used human heart samples and human induced pluripotent stem cell−cardiomyocytes (iPSC-CMs) to assess how SaO(2) affects human CM cell cycle activities. The results showed that there were significantly more cell cycle markers in the moderate hypoxia group (SaO(2): 75% to 85%) than in the other 2 groups (SaO(2) <75% or >85%). In iPSC-CMs 15% and 10% oxygen (O(2)) treatment increased cell cycle markers, whereas 5% and rapid change of O(2) decreased the markers. Moderate hypoxia is beneficial to the cell cycle activities of post-natal human CMs. Elsevier 2020-04-22 /pmc/articles/PMC7251192/ /pubmed/32478207 http://dx.doi.org/10.1016/j.jacbts.2020.02.008 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle PRECLINICAL RESEARCH
Ye, Lincai
Qiu, Lisheng
Feng, Bei
Jiang, Chuan
Huang, Yanhui
Zhang, Haibo
Zhang, Hao
Hong, Haifa
Liu, Jinfen
Role of Blood Oxygen Saturation During Post-Natal Human Cardiomyocyte Cell Cycle Activities
title Role of Blood Oxygen Saturation During Post-Natal Human Cardiomyocyte Cell Cycle Activities
title_full Role of Blood Oxygen Saturation During Post-Natal Human Cardiomyocyte Cell Cycle Activities
title_fullStr Role of Blood Oxygen Saturation During Post-Natal Human Cardiomyocyte Cell Cycle Activities
title_full_unstemmed Role of Blood Oxygen Saturation During Post-Natal Human Cardiomyocyte Cell Cycle Activities
title_short Role of Blood Oxygen Saturation During Post-Natal Human Cardiomyocyte Cell Cycle Activities
title_sort role of blood oxygen saturation during post-natal human cardiomyocyte cell cycle activities
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251192/
https://www.ncbi.nlm.nih.gov/pubmed/32478207
http://dx.doi.org/10.1016/j.jacbts.2020.02.008
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