The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site

The HIV-1 envelope glycoproteins (Env) undergo conformational changes upon interaction of the gp120 exterior glycoprotein with the CD4 receptor. The gp120 inner domain topological layers facilitate the transition of Env to the CD4-bound conformation. CD4 engages gp120 by introducing its phenylalanin...

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Detalles Bibliográficos
Autores principales: Prévost, Jérémie, Tolbert, William D., Medjahed, Halima, Sherburn, Rebekah T., Madani, Navid, Zoubchenok, Daria, Gendron-Lepage, Gabrielle, Gaffney, Althea E., Grenier, Melissa C., Kirk, Sharon, Vergara, Natasha, Han, Changze, Mann, Brendan T., Chénine, Agnès L., Ahmed, Adel, Chaiken, Irwin, Kirchhoff, Frank, Hahn, Beatrice H., Haim, Hillel, Abrams, Cameron F., Smith, Amos B., Sodroski, Joseph, Pazgier, Marzena, Finzi, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251204/
https://www.ncbi.nlm.nih.gov/pubmed/32457241
http://dx.doi.org/10.1128/mBio.00280-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251204/
https://www.ncbi.nlm.nih.gov/pubmed/32457241
http://dx.doi.org/10.1128/mBio.00280-20

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