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The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site
The HIV-1 envelope glycoproteins (Env) undergo conformational changes upon interaction of the gp120 exterior glycoprotein with the CD4 receptor. The gp120 inner domain topological layers facilitate the transition of Env to the CD4-bound conformation. CD4 engages gp120 by introducing its phenylalanin...
Autores principales: | Prévost, Jérémie, Tolbert, William D., Medjahed, Halima, Sherburn, Rebekah T., Madani, Navid, Zoubchenok, Daria, Gendron-Lepage, Gabrielle, Gaffney, Althea E., Grenier, Melissa C., Kirk, Sharon, Vergara, Natasha, Han, Changze, Mann, Brendan T., Chénine, Agnès L., Ahmed, Adel, Chaiken, Irwin, Kirchhoff, Frank, Hahn, Beatrice H., Haim, Hillel, Abrams, Cameron F., Smith, Amos B., Sodroski, Joseph, Pazgier, Marzena, Finzi, Andrés |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251204/ https://www.ncbi.nlm.nih.gov/pubmed/32457241 http://dx.doi.org/10.1128/mBio.00280-20 |
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