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Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies

PURPOSE: Proteases play an essential role in the pathophysiology of inflammatory bowel disease (IBD), contributing to the intestinal mucosal lesions through the degradation of the extracellular matrix and alteration of the barrier function. Ulcerative colitis (UC) is characterized by an extensive in...

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Detalles Bibliográficos
Autores principales:	Curciarello, Renata, Sobande, Toni, Jones, Samantha, Giuffrida, Paolo, Di Sabatino, Antonio, Docena, Guillermo H, MacDonald, Thomas T, Kok, Klaartje
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251227/ https://www.ncbi.nlm.nih.gov/pubmed/32547155 http://dx.doi.org/10.2147/JIR.S234710

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