Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis

Coronavirus disease 2019 (COVID-19) infection has now reached a pandemic state, affecting more than a million patients worldwide. Predictors of disease outcomes in these patients need to be urgently assessed to decrease morbidity and societal burden. Lactate dehydrogenase (LDH) has been associated w...

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Autores principales: Henry, Brandon Michael, Aggarwal, Gaurav, Wong, Johnny, Benoit, Stefanie, Vikse, Jens, Plebani, Mario, Lippi, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251362/
https://www.ncbi.nlm.nih.gov/pubmed/32738466
http://dx.doi.org/10.1016/j.ajem.2020.05.073
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author Henry, Brandon Michael
Aggarwal, Gaurav
Wong, Johnny
Benoit, Stefanie
Vikse, Jens
Plebani, Mario
Lippi, Giuseppe
author_facet Henry, Brandon Michael
Aggarwal, Gaurav
Wong, Johnny
Benoit, Stefanie
Vikse, Jens
Plebani, Mario
Lippi, Giuseppe
author_sort Henry, Brandon Michael
collection PubMed
description Coronavirus disease 2019 (COVID-19) infection has now reached a pandemic state, affecting more than a million patients worldwide. Predictors of disease outcomes in these patients need to be urgently assessed to decrease morbidity and societal burden. Lactate dehydrogenase (LDH) has been associated with worse outcomes in patients with viral infections. In this pooled analysis of 9 published studies (n = 1532 COVID-19 patients), we evaluated the association between elevated LDH levels measured at earliest time point in hospitalization and disease outcomes in patients with COVID-19. Elevated LDH levels were associated with a ~6-fold increase in odds of developing severe disease and a ~16-fold increase in odds of mortality in patients with COVID-19. Larger studies are needed to confirm these findings.
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spelling pubmed-72513622020-05-27 Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis Henry, Brandon Michael Aggarwal, Gaurav Wong, Johnny Benoit, Stefanie Vikse, Jens Plebani, Mario Lippi, Giuseppe Am J Emerg Med Article Coronavirus disease 2019 (COVID-19) infection has now reached a pandemic state, affecting more than a million patients worldwide. Predictors of disease outcomes in these patients need to be urgently assessed to decrease morbidity and societal burden. Lactate dehydrogenase (LDH) has been associated with worse outcomes in patients with viral infections. In this pooled analysis of 9 published studies (n = 1532 COVID-19 patients), we evaluated the association between elevated LDH levels measured at earliest time point in hospitalization and disease outcomes in patients with COVID-19. Elevated LDH levels were associated with a ~6-fold increase in odds of developing severe disease and a ~16-fold increase in odds of mortality in patients with COVID-19. Larger studies are needed to confirm these findings. Elsevier Inc. 2020-09 2020-05-27 /pmc/articles/PMC7251362/ /pubmed/32738466 http://dx.doi.org/10.1016/j.ajem.2020.05.073 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Henry, Brandon Michael
Aggarwal, Gaurav
Wong, Johnny
Benoit, Stefanie
Vikse, Jens
Plebani, Mario
Lippi, Giuseppe
Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis
title Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis
title_full Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis
title_fullStr Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis
title_full_unstemmed Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis
title_short Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis
title_sort lactate dehydrogenase levels predict coronavirus disease 2019 (covid-19) severity and mortality: a pooled analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251362/
https://www.ncbi.nlm.nih.gov/pubmed/32738466
http://dx.doi.org/10.1016/j.ajem.2020.05.073
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