Determining the unbinding events and conserved motions associated with the pyrazinamide release due to resistance mutations of Mycobacterium tuberculosis pyrazinamidase

Pyrazinamide (PZA) is the only first-line antitubercular drug active against latent Mycobacterium tuberculosis (Mtb). It is activated to pyrazinoic acid by the pncA-encoded pyrazinamidase enzyme (PZase). Despite the emergence of PZA drug resistance, the underlying mechanisms of resistance remain unc...

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Detalles Bibliográficos
Autores principales: Sheik Amamuddy, Olivier, Musyoka, Thommas Mutemi, Boateng, Rita Afriyie, Zabo, Sophakama, Tastan Bishop, Özlem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251373/
https://www.ncbi.nlm.nih.gov/pubmed/32489525
http://dx.doi.org/10.1016/j.csbj.2020.05.009

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