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Partial reduction of amyloid β production by β-secretase inhibitors does not decrease synaptic transmission

BACKGROUND: Alzheimer’s disease (AD) is the most common form of age-related neurodegenerative diseases. Cerebral deposition of Aβ peptides, especially Aβ42, is considered the major neuropathological hallmark of AD and the putative cause of AD-related neurotoxicity. Aβ peptides are produced by sequen...

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Detalles Bibliográficos
Autores principales:	Satir, Tugce Munise, Agholme, Lotta, Karlsson, Anna, Karlsson, Mattias, Karila, Paul, Illes, Sebastian, Bergström, Petra, Zetterberg, Henrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251689/ https://www.ncbi.nlm.nih.gov/pubmed/32456694 http://dx.doi.org/10.1186/s13195-020-00635-0

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