Cargando…

Increased plasma lipoprotein-associated phospholipase A2 levels are associated with coronary slow flow

OBJECTIVE: Coronary slow flow (CSF) is characterized by delayed opacification of distal epicardial coronary arteries without significant coronary stenosis. In addition, The changes of lipoprotein-associated phospholipase A2 (Lp-PLA(2)) as a significant predictive factor for CSF remain controversial....

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Yao-dong, Pei, Yu-qiang, Wang, Rui, Yang, Jia-xing, Zhao, Yin-xin, Liu, Xiao-li, Shen, Hua, Ma, Qian, Zhang, Shuo, Ge, Hai-long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251718/
https://www.ncbi.nlm.nih.gov/pubmed/32460702
http://dx.doi.org/10.1186/s12872-020-01463-8
_version_ 1783539013030772736
author Ding, Yao-dong
Pei, Yu-qiang
Wang, Rui
Yang, Jia-xing
Zhao, Yin-xin
Liu, Xiao-li
Shen, Hua
Ma, Qian
Zhang, Shuo
Ge, Hai-long
author_facet Ding, Yao-dong
Pei, Yu-qiang
Wang, Rui
Yang, Jia-xing
Zhao, Yin-xin
Liu, Xiao-li
Shen, Hua
Ma, Qian
Zhang, Shuo
Ge, Hai-long
author_sort Ding, Yao-dong
collection PubMed
description OBJECTIVE: Coronary slow flow (CSF) is characterized by delayed opacification of distal epicardial coronary arteries without significant coronary stenosis. In addition, The changes of lipoprotein-associated phospholipase A2 (Lp-PLA(2)) as a significant predictive factor for CSF remain controversial. The study aims to investigate the association between plasma Lp-PLA(2) and CSF. METHODS: In this retrospective study, 170 consecutive patients who underwent coronary angiography were enrolled in Beijing Anzhen Hospital from January 2017 to September 2019, and were divided into CSF group and normal control groups. According to coronary blood flow rate measured by the thrombolysis in myocardial infarction frame count (TFC) method, CSF was defined as TFC > 27. Serum Lp-PLA(2) levels were measured in an enzyme-linked immunosorbent assay. RESULTS: Lp-PLA(2) levels were higher in the CSF group than in the control group (288.6 ± 50.3 versus 141.9 ± 49.7, P < 0.001) and were significantly correlated with the mean coronary artery thrombolysis in myocardial infarction (TIMI) frame count (r = 0.790, P<0.001). Logistic regression analysis showed that high Lp-PLA(2) was independently associated with CSF after adjustment for conventional risk factors (OR = 1.040, CI = 1.022–1.059, P<0.001). Male sex (OR = 2.192, CI = 1.161–4.140, P = 0.016) and hypertension (OR = 1.965, CI = 1.034–3.736, P = 0.039) were also CSF risk factors. Receiver-operating characteristic curve (ROC) analysis showed that Lp-PLA(2) levels can predict CSF severity; the predictive power was higher than the other risk factors. CONCLUSION: Our study demonstrated that patients with CSF had higher circulating levels of Lp-PLA(2) than normal controls. After adjustment for potential confounders, increased Lp-PLA(2) was independently associated with presence of CSF.
format Online
Article
Text
id pubmed-7251718
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-72517182020-06-04 Increased plasma lipoprotein-associated phospholipase A2 levels are associated with coronary slow flow Ding, Yao-dong Pei, Yu-qiang Wang, Rui Yang, Jia-xing Zhao, Yin-xin Liu, Xiao-li Shen, Hua Ma, Qian Zhang, Shuo Ge, Hai-long BMC Cardiovasc Disord Research Article OBJECTIVE: Coronary slow flow (CSF) is characterized by delayed opacification of distal epicardial coronary arteries without significant coronary stenosis. In addition, The changes of lipoprotein-associated phospholipase A2 (Lp-PLA(2)) as a significant predictive factor for CSF remain controversial. The study aims to investigate the association between plasma Lp-PLA(2) and CSF. METHODS: In this retrospective study, 170 consecutive patients who underwent coronary angiography were enrolled in Beijing Anzhen Hospital from January 2017 to September 2019, and were divided into CSF group and normal control groups. According to coronary blood flow rate measured by the thrombolysis in myocardial infarction frame count (TFC) method, CSF was defined as TFC > 27. Serum Lp-PLA(2) levels were measured in an enzyme-linked immunosorbent assay. RESULTS: Lp-PLA(2) levels were higher in the CSF group than in the control group (288.6 ± 50.3 versus 141.9 ± 49.7, P < 0.001) and were significantly correlated with the mean coronary artery thrombolysis in myocardial infarction (TIMI) frame count (r = 0.790, P<0.001). Logistic regression analysis showed that high Lp-PLA(2) was independently associated with CSF after adjustment for conventional risk factors (OR = 1.040, CI = 1.022–1.059, P<0.001). Male sex (OR = 2.192, CI = 1.161–4.140, P = 0.016) and hypertension (OR = 1.965, CI = 1.034–3.736, P = 0.039) were also CSF risk factors. Receiver-operating characteristic curve (ROC) analysis showed that Lp-PLA(2) levels can predict CSF severity; the predictive power was higher than the other risk factors. CONCLUSION: Our study demonstrated that patients with CSF had higher circulating levels of Lp-PLA(2) than normal controls. After adjustment for potential confounders, increased Lp-PLA(2) was independently associated with presence of CSF. BioMed Central 2020-05-27 /pmc/articles/PMC7251718/ /pubmed/32460702 http://dx.doi.org/10.1186/s12872-020-01463-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Ding, Yao-dong
Pei, Yu-qiang
Wang, Rui
Yang, Jia-xing
Zhao, Yin-xin
Liu, Xiao-li
Shen, Hua
Ma, Qian
Zhang, Shuo
Ge, Hai-long
Increased plasma lipoprotein-associated phospholipase A2 levels are associated with coronary slow flow
title Increased plasma lipoprotein-associated phospholipase A2 levels are associated with coronary slow flow
title_full Increased plasma lipoprotein-associated phospholipase A2 levels are associated with coronary slow flow
title_fullStr Increased plasma lipoprotein-associated phospholipase A2 levels are associated with coronary slow flow
title_full_unstemmed Increased plasma lipoprotein-associated phospholipase A2 levels are associated with coronary slow flow
title_short Increased plasma lipoprotein-associated phospholipase A2 levels are associated with coronary slow flow
title_sort increased plasma lipoprotein-associated phospholipase a2 levels are associated with coronary slow flow
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251718/
https://www.ncbi.nlm.nih.gov/pubmed/32460702
http://dx.doi.org/10.1186/s12872-020-01463-8
work_keys_str_mv AT dingyaodong increasedplasmalipoproteinassociatedphospholipasea2levelsareassociatedwithcoronaryslowflow
AT peiyuqiang increasedplasmalipoproteinassociatedphospholipasea2levelsareassociatedwithcoronaryslowflow
AT wangrui increasedplasmalipoproteinassociatedphospholipasea2levelsareassociatedwithcoronaryslowflow
AT yangjiaxing increasedplasmalipoproteinassociatedphospholipasea2levelsareassociatedwithcoronaryslowflow
AT zhaoyinxin increasedplasmalipoproteinassociatedphospholipasea2levelsareassociatedwithcoronaryslowflow
AT liuxiaoli increasedplasmalipoproteinassociatedphospholipasea2levelsareassociatedwithcoronaryslowflow
AT shenhua increasedplasmalipoproteinassociatedphospholipasea2levelsareassociatedwithcoronaryslowflow
AT maqian increasedplasmalipoproteinassociatedphospholipasea2levelsareassociatedwithcoronaryslowflow
AT zhangshuo increasedplasmalipoproteinassociatedphospholipasea2levelsareassociatedwithcoronaryslowflow
AT gehailong increasedplasmalipoproteinassociatedphospholipasea2levelsareassociatedwithcoronaryslowflow