VL30 retrotransposition is associated with induced EMT, CSC generation and tumorigenesis in HC11 mouse mammary stem-like epithelial cells

Retrotransposons copy their sequences via an RNA intermediate, followed by reverse transcription into cDNA and random insertion, into a new genomic locus. New retrotransposon copies may lead to cell transformation and/or tumorigenesis through insertional mutagenesis. Methylation is a major defense m...

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Detalles Bibliográficos
Autores principales: Thrasyvoulou, Soteroula, Vartholomatos, Georgios, Markopoulos, Georgios, Noutsopoulos, Dimitrios, Mantziou, Stefania, Gkartziou, Foteini, Papageorgis, Panagiotis, Charchanti, Antonia, Kouklis, Panos, Constantinou, Andreas I., Tzavaras, Theodore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251778/
https://www.ncbi.nlm.nih.gov/pubmed/32377731
http://dx.doi.org/10.3892/or.2020.7596

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