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Controlled Transdermal Release of Antioxidant Ferulate by a Porous Sc(III) MOF
The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells), and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antio...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251947/ https://www.ncbi.nlm.nih.gov/pubmed/32450520 http://dx.doi.org/10.1016/j.isci.2020.101156 |
| _version_ | 1783539057673895936 |
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| author | Osorio-Toribio, Génesis Velásquez-Hernández, Miriam de J. Mileo, Paulo G.M. Zárate, J. Antonio Aguila-Rosas, Javier Leyva-Gómez, Gerardo Sánchez-Sánchez, Roberto Magaña, Jonathan J. Pérez-Díaz, Mario Alberto Lázaro, Isabel Abánades Forgan, Ross S. Maurin, Guillaume Lima, Enrique Ibarra, Ilich A. |
| author_facet | Osorio-Toribio, Génesis Velásquez-Hernández, Miriam de J. Mileo, Paulo G.M. Zárate, J. Antonio Aguila-Rosas, Javier Leyva-Gómez, Gerardo Sánchez-Sánchez, Roberto Magaña, Jonathan J. Pérez-Díaz, Mario Alberto Lázaro, Isabel Abánades Forgan, Ross S. Maurin, Guillaume Lima, Enrique Ibarra, Ilich A. |
| author_sort | Osorio-Toribio, Génesis |
| collection | PubMed |
| description | The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells), and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antioxidant pharmacological effects of ferulate while enhancing the bio-preservation of dermal skin fibroblasts, during the delivery process. These discoveries pave the way toward the extended use of Sc(III)-based MOFs as drug delivery systems (DDSs). |
| format | Online Article Text |
| id | pubmed-7251947 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-72519472020-05-29 Controlled Transdermal Release of Antioxidant Ferulate by a Porous Sc(III) MOF Osorio-Toribio, Génesis Velásquez-Hernández, Miriam de J. Mileo, Paulo G.M. Zárate, J. Antonio Aguila-Rosas, Javier Leyva-Gómez, Gerardo Sánchez-Sánchez, Roberto Magaña, Jonathan J. Pérez-Díaz, Mario Alberto Lázaro, Isabel Abánades Forgan, Ross S. Maurin, Guillaume Lima, Enrique Ibarra, Ilich A. iScience Article The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells), and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antioxidant pharmacological effects of ferulate while enhancing the bio-preservation of dermal skin fibroblasts, during the delivery process. These discoveries pave the way toward the extended use of Sc(III)-based MOFs as drug delivery systems (DDSs). Elsevier 2020-05-11 /pmc/articles/PMC7251947/ /pubmed/32450520 http://dx.doi.org/10.1016/j.isci.2020.101156 Text en Crown Copyright © 2020. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Article Osorio-Toribio, Génesis Velásquez-Hernández, Miriam de J. Mileo, Paulo G.M. Zárate, J. Antonio Aguila-Rosas, Javier Leyva-Gómez, Gerardo Sánchez-Sánchez, Roberto Magaña, Jonathan J. Pérez-Díaz, Mario Alberto Lázaro, Isabel Abánades Forgan, Ross S. Maurin, Guillaume Lima, Enrique Ibarra, Ilich A. Controlled Transdermal Release of Antioxidant Ferulate by a Porous Sc(III) MOF |
| title | Controlled Transdermal Release of Antioxidant Ferulate by a Porous Sc(III) MOF |
| title_full | Controlled Transdermal Release of Antioxidant Ferulate by a Porous Sc(III) MOF |
| title_fullStr | Controlled Transdermal Release of Antioxidant Ferulate by a Porous Sc(III) MOF |
| title_full_unstemmed | Controlled Transdermal Release of Antioxidant Ferulate by a Porous Sc(III) MOF |
| title_short | Controlled Transdermal Release of Antioxidant Ferulate by a Porous Sc(III) MOF |
| title_sort | controlled transdermal release of antioxidant ferulate by a porous sc(iii) mof |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251947/ https://www.ncbi.nlm.nih.gov/pubmed/32450520 http://dx.doi.org/10.1016/j.isci.2020.101156 |
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