Cargando…

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-CoV-2 spike (S) protein binds angiotensin-converting enzyme 2 (ACE2), and in concert with host proteases, principally transmembr...

Descripción completa

Detalles Bibliográficos
Autores principales: Ziegler, Carly G.K., Allon, Samuel J., Nyquist, Sarah K., Mbano, Ian M., Miao, Vincent N., Tzouanas, Constantine N., Cao, Yuming, Yousif, Ashraf S., Bals, Julia, Hauser, Blake M., Feldman, Jared, Muus, Christoph, Wadsworth, Marc H., Kazer, Samuel W., Hughes, Travis K., Doran, Benjamin, Gatter, G. James, Vukovic, Marko, Taliaferro, Faith, Mead, Benjamin E., Guo, Zhiru, Wang, Jennifer P., Gras, Delphine, Plaisant, Magali, Ansari, Meshal, Angelidis, Ilias, Adler, Heiko, Sucre, Jennifer M.S., Taylor, Chase J., Lin, Brian, Waghray, Avinash, Mitsialis, Vanessa, Dwyer, Daniel F., Buchheit, Kathleen M., Boyce, Joshua A., Barrett, Nora A., Laidlaw, Tanya M., Carroll, Shaina L., Colonna, Lucrezia, Tkachev, Victor, Peterson, Christopher W., Yu, Alison, Zheng, Hengqi Betty, Gideon, Hannah P., Winchell, Caylin G., Lin, Philana Ling, Bingle, Colin D., Snapper, Scott B., Kropski, Jonathan A., Theis, Fabian J., Schiller, Herbert B., Zaragosi, Laure-Emmanuelle, Barbry, Pascal, Leslie, Alasdair, Kiem, Hans-Peter, Flynn, JoAnne L., Fortune, Sarah M., Berger, Bonnie, Finberg, Robert W., Kean, Leslie S., Garber, Manuel, Schmidt, Aaron G., Lingwood, Daniel, Shalek, Alex K., Ordovas-Montanes, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252096/
https://www.ncbi.nlm.nih.gov/pubmed/32413319
http://dx.doi.org/10.1016/j.cell.2020.04.035
_version_ 1783539089217159168
author Ziegler, Carly G.K.
Allon, Samuel J.
Nyquist, Sarah K.
Mbano, Ian M.
Miao, Vincent N.
Tzouanas, Constantine N.
Cao, Yuming
Yousif, Ashraf S.
Bals, Julia
Hauser, Blake M.
Feldman, Jared
Muus, Christoph
Wadsworth, Marc H.
Kazer, Samuel W.
Hughes, Travis K.
Doran, Benjamin
Gatter, G. James
Vukovic, Marko
Taliaferro, Faith
Mead, Benjamin E.
Guo, Zhiru
Wang, Jennifer P.
Gras, Delphine
Plaisant, Magali
Ansari, Meshal
Angelidis, Ilias
Adler, Heiko
Sucre, Jennifer M.S.
Taylor, Chase J.
Lin, Brian
Waghray, Avinash
Mitsialis, Vanessa
Dwyer, Daniel F.
Buchheit, Kathleen M.
Boyce, Joshua A.
Barrett, Nora A.
Laidlaw, Tanya M.
Carroll, Shaina L.
Colonna, Lucrezia
Tkachev, Victor
Peterson, Christopher W.
Yu, Alison
Zheng, Hengqi Betty
Gideon, Hannah P.
Winchell, Caylin G.
Lin, Philana Ling
Bingle, Colin D.
Snapper, Scott B.
Kropski, Jonathan A.
Theis, Fabian J.
Schiller, Herbert B.
Zaragosi, Laure-Emmanuelle
Barbry, Pascal
Leslie, Alasdair
Kiem, Hans-Peter
Flynn, JoAnne L.
Fortune, Sarah M.
Berger, Bonnie
Finberg, Robert W.
Kean, Leslie S.
Garber, Manuel
Schmidt, Aaron G.
Lingwood, Daniel
Shalek, Alex K.
Ordovas-Montanes, Jose
author_facet Ziegler, Carly G.K.
Allon, Samuel J.
Nyquist, Sarah K.
Mbano, Ian M.
Miao, Vincent N.
Tzouanas, Constantine N.
Cao, Yuming
Yousif, Ashraf S.
Bals, Julia
Hauser, Blake M.
Feldman, Jared
Muus, Christoph
Wadsworth, Marc H.
Kazer, Samuel W.
Hughes, Travis K.
Doran, Benjamin
Gatter, G. James
Vukovic, Marko
Taliaferro, Faith
Mead, Benjamin E.
Guo, Zhiru
Wang, Jennifer P.
Gras, Delphine
Plaisant, Magali
Ansari, Meshal
Angelidis, Ilias
Adler, Heiko
Sucre, Jennifer M.S.
Taylor, Chase J.
Lin, Brian
Waghray, Avinash
Mitsialis, Vanessa
Dwyer, Daniel F.
Buchheit, Kathleen M.
Boyce, Joshua A.
Barrett, Nora A.
Laidlaw, Tanya M.
Carroll, Shaina L.
Colonna, Lucrezia
Tkachev, Victor
Peterson, Christopher W.
Yu, Alison
Zheng, Hengqi Betty
Gideon, Hannah P.
Winchell, Caylin G.
Lin, Philana Ling
Bingle, Colin D.
Snapper, Scott B.
Kropski, Jonathan A.
Theis, Fabian J.
Schiller, Herbert B.
Zaragosi, Laure-Emmanuelle
Barbry, Pascal
Leslie, Alasdair
Kiem, Hans-Peter
Flynn, JoAnne L.
Fortune, Sarah M.
Berger, Bonnie
Finberg, Robert W.
Kean, Leslie S.
Garber, Manuel
Schmidt, Aaron G.
Lingwood, Daniel
Shalek, Alex K.
Ordovas-Montanes, Jose
author_sort Ziegler, Carly G.K.
collection PubMed
description There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-CoV-2 spike (S) protein binds angiotensin-converting enzyme 2 (ACE2), and in concert with host proteases, principally transmembrane serine protease 2 (TMPRSS2), promotes cellular entry. The cell subsets targeted by SARS-CoV-2 in host tissues and the factors that regulate ACE2 expression remain unknown. Here, we leverage human, non-human primate, and mouse single-cell RNA-sequencing (scRNA-seq) datasets across health and disease to uncover putative targets of SARS-CoV-2 among tissue-resident cell subsets. We identify ACE2 and TMPRSS2 co-expressing cells within lung type II pneumocytes, ileal absorptive enterocytes, and nasal goblet secretory cells. Strikingly, we discovered that ACE2 is a human interferon-stimulated gene (ISG) in vitro using airway epithelial cells and extend our findings to in vivo viral infections. Our data suggest that SARS-CoV-2 could exploit species-specific interferon-driven upregulation of ACE2, a tissue-protective mediator during lung injury, to enhance infection.
format Online
Article
Text
id pubmed-7252096
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Cell Press
record_format MEDLINE/PubMed
spelling pubmed-72520962020-05-28 SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues Ziegler, Carly G.K. Allon, Samuel J. Nyquist, Sarah K. Mbano, Ian M. Miao, Vincent N. Tzouanas, Constantine N. Cao, Yuming Yousif, Ashraf S. Bals, Julia Hauser, Blake M. Feldman, Jared Muus, Christoph Wadsworth, Marc H. Kazer, Samuel W. Hughes, Travis K. Doran, Benjamin Gatter, G. James Vukovic, Marko Taliaferro, Faith Mead, Benjamin E. Guo, Zhiru Wang, Jennifer P. Gras, Delphine Plaisant, Magali Ansari, Meshal Angelidis, Ilias Adler, Heiko Sucre, Jennifer M.S. Taylor, Chase J. Lin, Brian Waghray, Avinash Mitsialis, Vanessa Dwyer, Daniel F. Buchheit, Kathleen M. Boyce, Joshua A. Barrett, Nora A. Laidlaw, Tanya M. Carroll, Shaina L. Colonna, Lucrezia Tkachev, Victor Peterson, Christopher W. Yu, Alison Zheng, Hengqi Betty Gideon, Hannah P. Winchell, Caylin G. Lin, Philana Ling Bingle, Colin D. Snapper, Scott B. Kropski, Jonathan A. Theis, Fabian J. Schiller, Herbert B. Zaragosi, Laure-Emmanuelle Barbry, Pascal Leslie, Alasdair Kiem, Hans-Peter Flynn, JoAnne L. Fortune, Sarah M. Berger, Bonnie Finberg, Robert W. Kean, Leslie S. Garber, Manuel Schmidt, Aaron G. Lingwood, Daniel Shalek, Alex K. Ordovas-Montanes, Jose Cell Article There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-CoV-2 spike (S) protein binds angiotensin-converting enzyme 2 (ACE2), and in concert with host proteases, principally transmembrane serine protease 2 (TMPRSS2), promotes cellular entry. The cell subsets targeted by SARS-CoV-2 in host tissues and the factors that regulate ACE2 expression remain unknown. Here, we leverage human, non-human primate, and mouse single-cell RNA-sequencing (scRNA-seq) datasets across health and disease to uncover putative targets of SARS-CoV-2 among tissue-resident cell subsets. We identify ACE2 and TMPRSS2 co-expressing cells within lung type II pneumocytes, ileal absorptive enterocytes, and nasal goblet secretory cells. Strikingly, we discovered that ACE2 is a human interferon-stimulated gene (ISG) in vitro using airway epithelial cells and extend our findings to in vivo viral infections. Our data suggest that SARS-CoV-2 could exploit species-specific interferon-driven upregulation of ACE2, a tissue-protective mediator during lung injury, to enhance infection. Cell Press 2020-05-28 /pmc/articles/PMC7252096/ /pubmed/32413319 http://dx.doi.org/10.1016/j.cell.2020.04.035 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ziegler, Carly G.K.
Allon, Samuel J.
Nyquist, Sarah K.
Mbano, Ian M.
Miao, Vincent N.
Tzouanas, Constantine N.
Cao, Yuming
Yousif, Ashraf S.
Bals, Julia
Hauser, Blake M.
Feldman, Jared
Muus, Christoph
Wadsworth, Marc H.
Kazer, Samuel W.
Hughes, Travis K.
Doran, Benjamin
Gatter, G. James
Vukovic, Marko
Taliaferro, Faith
Mead, Benjamin E.
Guo, Zhiru
Wang, Jennifer P.
Gras, Delphine
Plaisant, Magali
Ansari, Meshal
Angelidis, Ilias
Adler, Heiko
Sucre, Jennifer M.S.
Taylor, Chase J.
Lin, Brian
Waghray, Avinash
Mitsialis, Vanessa
Dwyer, Daniel F.
Buchheit, Kathleen M.
Boyce, Joshua A.
Barrett, Nora A.
Laidlaw, Tanya M.
Carroll, Shaina L.
Colonna, Lucrezia
Tkachev, Victor
Peterson, Christopher W.
Yu, Alison
Zheng, Hengqi Betty
Gideon, Hannah P.
Winchell, Caylin G.
Lin, Philana Ling
Bingle, Colin D.
Snapper, Scott B.
Kropski, Jonathan A.
Theis, Fabian J.
Schiller, Herbert B.
Zaragosi, Laure-Emmanuelle
Barbry, Pascal
Leslie, Alasdair
Kiem, Hans-Peter
Flynn, JoAnne L.
Fortune, Sarah M.
Berger, Bonnie
Finberg, Robert W.
Kean, Leslie S.
Garber, Manuel
Schmidt, Aaron G.
Lingwood, Daniel
Shalek, Alex K.
Ordovas-Montanes, Jose
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
title SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
title_full SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
title_fullStr SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
title_full_unstemmed SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
title_short SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
title_sort sars-cov-2 receptor ace2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252096/
https://www.ncbi.nlm.nih.gov/pubmed/32413319
http://dx.doi.org/10.1016/j.cell.2020.04.035
work_keys_str_mv AT zieglercarlygk sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT allonsamuelj sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT nyquistsarahk sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT mbanoianm sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT miaovincentn sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT tzouanasconstantinen sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT caoyuming sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT yousifashrafs sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT balsjulia sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT hauserblakem sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT feldmanjared sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT muuschristoph sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT wadsworthmarch sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT kazersamuelw sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT hughestravisk sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT doranbenjamin sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT gattergjames sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT vukovicmarko sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT taliaferrofaith sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT meadbenjamine sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT guozhiru sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT wangjenniferp sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT grasdelphine sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT plaisantmagali sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT ansarimeshal sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT angelidisilias sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT adlerheiko sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT sucrejenniferms sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT taylorchasej sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT linbrian sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT waghrayavinash sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT mitsialisvanessa sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT dwyerdanielf sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT buchheitkathleenm sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT boycejoshuaa sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT barrettnoraa sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT laidlawtanyam sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT carrollshainal sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT colonnalucrezia sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT tkachevvictor sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT petersonchristopherw sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT yualison sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT zhenghengqibetty sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT gideonhannahp sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT winchellcayling sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT linphilanaling sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT binglecolind sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT snapperscottb sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT kropskijonathana sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT theisfabianj sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT schillerherbertb sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT zaragosilaureemmanuelle sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT barbrypascal sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT lesliealasdair sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT kiemhanspeter sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT flynnjoannel sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT fortunesarahm sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT bergerbonnie sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT finbergrobertw sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT keanleslies sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT garbermanuel sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT schmidtaarong sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT lingwooddaniel sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT shalekalexk sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT ordovasmontanesjose sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues
AT sarscov2receptorace2isaninterferonstimulatedgeneinhumanairwayepithelialcellsandisdetectedinspecificcellsubsetsacrosstissues