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Advances in circular RNAs and their role in glioma (Review)
Glioma is the most common primary tumour of the central nervous system, and is associated with a high postoperative recurrence rate and resistance to chemotherapy. High-grade glioblastoma in particular has a very poor prognosis and poses a serious threat to human health. Related studies have confirm...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252450/ https://www.ncbi.nlm.nih.gov/pubmed/32319596 http://dx.doi.org/10.3892/ijo.2020.5049 |
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author | Zhang, Yuhao Lin, Xiaomeng Geng, Xiuchao Shi, Liang Li, Qiang Liu, Fulin Fang, Chuan Wang, Hong |
author_facet | Zhang, Yuhao Lin, Xiaomeng Geng, Xiuchao Shi, Liang Li, Qiang Liu, Fulin Fang, Chuan Wang, Hong |
author_sort | Zhang, Yuhao |
collection | PubMed |
description | Glioma is the most common primary tumour of the central nervous system, and is associated with a high postoperative recurrence rate and resistance to chemotherapy. High-grade glioblastoma in particular has a very poor prognosis and poses a serious threat to human health. Related studies have confirmed that the occurrence and development of gliomas are closely associated with the abnormal expression and regulation of genes. Moreover, the number of studies on the association of the expression of non-coding RNAs [linear RNAs, microRNAs and circular RNAs (circRNAs)] in human cells with glioma has been gradually increasing in recent years. Among those, circRNAs, previously considered to be 'splicing errors', have been shown to be highly expressed in eukaryotic cells and regulate the biological behaviour of gliomas. circRNAs are highly abundant and stable, and have become a research hotspot in the field of glioma molecular biology. The aim of the present review was to focus on the research progress regarding the association between circRNA expression and gliomas, and to provide a theoretical basis according to the currently available literature for further exploring this association. The present study may be of value for the early diagnosis, pathological grading, targeted therapy and prognostic evaluation of gliomas. |
format | Online Article Text |
id | pubmed-7252450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-72524502020-05-28 Advances in circular RNAs and their role in glioma (Review) Zhang, Yuhao Lin, Xiaomeng Geng, Xiuchao Shi, Liang Li, Qiang Liu, Fulin Fang, Chuan Wang, Hong Int J Oncol Articles Glioma is the most common primary tumour of the central nervous system, and is associated with a high postoperative recurrence rate and resistance to chemotherapy. High-grade glioblastoma in particular has a very poor prognosis and poses a serious threat to human health. Related studies have confirmed that the occurrence and development of gliomas are closely associated with the abnormal expression and regulation of genes. Moreover, the number of studies on the association of the expression of non-coding RNAs [linear RNAs, microRNAs and circular RNAs (circRNAs)] in human cells with glioma has been gradually increasing in recent years. Among those, circRNAs, previously considered to be 'splicing errors', have been shown to be highly expressed in eukaryotic cells and regulate the biological behaviour of gliomas. circRNAs are highly abundant and stable, and have become a research hotspot in the field of glioma molecular biology. The aim of the present review was to focus on the research progress regarding the association between circRNA expression and gliomas, and to provide a theoretical basis according to the currently available literature for further exploring this association. The present study may be of value for the early diagnosis, pathological grading, targeted therapy and prognostic evaluation of gliomas. D.A. Spandidos 2020-04-16 /pmc/articles/PMC7252450/ /pubmed/32319596 http://dx.doi.org/10.3892/ijo.2020.5049 Text en Copyright: © Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Zhang, Yuhao Lin, Xiaomeng Geng, Xiuchao Shi, Liang Li, Qiang Liu, Fulin Fang, Chuan Wang, Hong Advances in circular RNAs and their role in glioma (Review) |
title | Advances in circular RNAs and their role in glioma (Review) |
title_full | Advances in circular RNAs and their role in glioma (Review) |
title_fullStr | Advances in circular RNAs and their role in glioma (Review) |
title_full_unstemmed | Advances in circular RNAs and their role in glioma (Review) |
title_short | Advances in circular RNAs and their role in glioma (Review) |
title_sort | advances in circular rnas and their role in glioma (review) |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252450/ https://www.ncbi.nlm.nih.gov/pubmed/32319596 http://dx.doi.org/10.3892/ijo.2020.5049 |
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