Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival

NAD, a key co-enzyme required for cell metabolism, is synthesized via two pathways in most organisms. Since schistosomes apparently lack enzymes required for de novo NAD biosynthesis, we evaluated whether these parasites, which infect >200 million people worldwide, maintain NAD homeostasis via th...

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Detalles Bibliográficos
Autores principales: Schultz, Michael D., Dadali, Tulin, Jacques, Sylvain A., Muller-Steffner, Hélène, Foote, Jeremy B., Sorci, Leonardo, Kellenberger, Esther, Botta, Davide, Lund, Frances E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252647/
https://www.ncbi.nlm.nih.gov/pubmed/32459815
http://dx.doi.org/10.1371/journal.ppat.1008539

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