Time in the Therapeutic Range (TTR): An Overly Simplified Conundrum

Anticoagulation with warfarin has been used for over 60 years; however, its administration is fraught with difficulty since many factors can affect warfarin dosing. The concept of time in therapeutic range (TTR) has become a popular way to report warfarin management and compare anticoagulation manag...

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Detalles Bibliográficos
Autor principal: Reiffel, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MediaSphere Medical 2017
Materias:
Research Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252837/
https://www.ncbi.nlm.nih.gov/pubmed/32494441
http://dx.doi.org/10.19102/icrm.2017.080302
Descripción
Sumario:Anticoagulation with warfarin has been used for over 60 years; however, its administration is fraught with difficulty since many factors can affect warfarin dosing. The concept of time in therapeutic range (TTR) has become a popular way to report warfarin management and compare anticoagulation management across clinical trials. However, TTR is a much more complex concept than most clinicians and trialists recognize. This manuscript attempts to discuss some of the important factors underlying this complexity and presents a suggestion to improve reports on TTR.

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