Time in the Therapeutic Range (TTR): An Overly Simplified Conundrum

Anticoagulation with warfarin has been used for over 60 years; however, its administration is fraught with difficulty since many factors can affect warfarin dosing. The concept of time in therapeutic range (TTR) has become a popular way to report warfarin management and compare anticoagulation manag...

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Detalles Bibliográficos
Autor principal: Reiffel, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MediaSphere Medical 2017
Materias:
Research Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252837/
https://www.ncbi.nlm.nih.gov/pubmed/32494441
http://dx.doi.org/10.19102/icrm.2017.080302
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author Reiffel, James A.
author_facet Reiffel, James A.
author_sort Reiffel, James A.
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description Anticoagulation with warfarin has been used for over 60 years; however, its administration is fraught with difficulty since many factors can affect warfarin dosing. The concept of time in therapeutic range (TTR) has become a popular way to report warfarin management and compare anticoagulation management across clinical trials. However, TTR is a much more complex concept than most clinicians and trialists recognize. This manuscript attempts to discuss some of the important factors underlying this complexity and presents a suggestion to improve reports on TTR.
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spelling pubmed-72528372020-06-02 Time in the Therapeutic Range (TTR): An Overly Simplified Conundrum Reiffel, James A. J Innov Card Rhythm Manag Research Review Anticoagulation with warfarin has been used for over 60 years; however, its administration is fraught with difficulty since many factors can affect warfarin dosing. The concept of time in therapeutic range (TTR) has become a popular way to report warfarin management and compare anticoagulation management across clinical trials. However, TTR is a much more complex concept than most clinicians and trialists recognize. This manuscript attempts to discuss some of the important factors underlying this complexity and presents a suggestion to improve reports on TTR. MediaSphere Medical 2017-03-15 /pmc/articles/PMC7252837/ /pubmed/32494441 http://dx.doi.org/10.19102/icrm.2017.080302 Text en Copyright: © 2017 Innovations in Cardiac Rhythm Management http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Review
Reiffel, James A.
Time in the Therapeutic Range (TTR): An Overly Simplified Conundrum
title Time in the Therapeutic Range (TTR): An Overly Simplified Conundrum
title_full Time in the Therapeutic Range (TTR): An Overly Simplified Conundrum
title_fullStr Time in the Therapeutic Range (TTR): An Overly Simplified Conundrum
title_full_unstemmed Time in the Therapeutic Range (TTR): An Overly Simplified Conundrum
title_short Time in the Therapeutic Range (TTR): An Overly Simplified Conundrum
title_sort time in the therapeutic range (ttr): an overly simplified conundrum
topic Research Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252837/
https://www.ncbi.nlm.nih.gov/pubmed/32494441
http://dx.doi.org/10.19102/icrm.2017.080302
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