Roles and Regulation of Voltage-gated Calcium Channels in Arrhythmias

Calcium flowing through voltage-dependent calcium channels into cardiomyocytes mediates excitation–contraction coupling, controls action-potential duration and automaticity in nodal cells, and regulates gene expression. Proper surface targeting and basal and hormonal regulation of calcium channels a...

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Detalles Bibliográficos
Autores principales: Kushner, Jared, Ferrer, Xavier, Marx, Steven O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MediaSphere Medical 2019
Materias:
Research Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252866/
https://www.ncbi.nlm.nih.gov/pubmed/32494407
http://dx.doi.org/10.19102/icrm.2019.101006
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author Kushner, Jared
Ferrer, Xavier
Marx, Steven O.
author_facet Kushner, Jared
Ferrer, Xavier
Marx, Steven O.
author_sort Kushner, Jared
collection PubMed
description Calcium flowing through voltage-dependent calcium channels into cardiomyocytes mediates excitation–contraction coupling, controls action-potential duration and automaticity in nodal cells, and regulates gene expression. Proper surface targeting and basal and hormonal regulation of calcium channels are vital for normal cardiac physiology. In this review, we discuss the roles of voltage-gated calcium channels in the heart and the mechanisms by which these channels are regulated by physiological signaling pathways in health and disease.
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spelling pubmed-72528662020-06-02 Roles and Regulation of Voltage-gated Calcium Channels in Arrhythmias Kushner, Jared Ferrer, Xavier Marx, Steven O. J Innov Card Rhythm Manag Research Review Calcium flowing through voltage-dependent calcium channels into cardiomyocytes mediates excitation–contraction coupling, controls action-potential duration and automaticity in nodal cells, and regulates gene expression. Proper surface targeting and basal and hormonal regulation of calcium channels are vital for normal cardiac physiology. In this review, we discuss the roles of voltage-gated calcium channels in the heart and the mechanisms by which these channels are regulated by physiological signaling pathways in health and disease. MediaSphere Medical 2019-10-15 /pmc/articles/PMC7252866/ /pubmed/32494407 http://dx.doi.org/10.19102/icrm.2019.101006 Text en Copyright: © 2019 Innovations in Cardiac Rhythm Management http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Review
Kushner, Jared
Ferrer, Xavier
Marx, Steven O.
Roles and Regulation of Voltage-gated Calcium Channels in Arrhythmias
title Roles and Regulation of Voltage-gated Calcium Channels in Arrhythmias
title_full Roles and Regulation of Voltage-gated Calcium Channels in Arrhythmias
title_fullStr Roles and Regulation of Voltage-gated Calcium Channels in Arrhythmias
title_full_unstemmed Roles and Regulation of Voltage-gated Calcium Channels in Arrhythmias
title_short Roles and Regulation of Voltage-gated Calcium Channels in Arrhythmias
title_sort roles and regulation of voltage-gated calcium channels in arrhythmias
topic Research Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252866/
https://www.ncbi.nlm.nih.gov/pubmed/32494407
http://dx.doi.org/10.19102/icrm.2019.101006
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AT ferrerxavier rolesandregulationofvoltagegatedcalciumchannelsinarrhythmias
AT marxsteveno rolesandregulationofvoltagegatedcalciumchannelsinarrhythmias

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