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Control of Ligand-Binding Specificity Using Photocleavable Linkers in AFM Force Spectroscopy
[Image: see text] In recent decades, atomic force microscopy (AFM), in particular the force spectroscopy mode, has become a method of choice to study biomolecular interactions at the single-molecule level. However, grafting procedures as well as determining binding specificity remain challenging. We...
Autores principales: | Koehler, Melanie, Lo Giudice, Cristina, Vogl, Philipp, Ebner, Andreas, Hinterdorfer, Peter, Gruber, Hermann J., Alsteens, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252943/ https://www.ncbi.nlm.nih.gov/pubmed/32320256 http://dx.doi.org/10.1021/acs.nanolett.0c01426 |
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