NKTR-214 immunotherapy synergizes with radiotherapy to stimulate systemic CD8(+) T cell responses capable of curing multi-focal cancer

BACKGROUND: High-dose radiotherapy (RT) is known to be immunogenic, but is rarely capable of driving clinically relevant abscopal antitumor immunity as monotherapy. RT is known to increase antigen presentation, type I/II interferon responses, and immune cell trafficking to irradiated tumors. Bempega...

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Detalles Bibliográficos
Autores principales: Walker, Joshua M, Rolig, Annah S, Charych, Deborah H, Hoch, Ute, Kasiewicz, Melissa J, Rose, Daniel C, McNamara, Michael J, Hilgart-Martiszus, Ian F, Redmond, William L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252958/
https://www.ncbi.nlm.nih.gov/pubmed/32457127
http://dx.doi.org/10.1136/jitc-2019-000464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252958/
https://www.ncbi.nlm.nih.gov/pubmed/32457127
http://dx.doi.org/10.1136/jitc-2019-000464

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