10-Valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine (PHiD-CV10) versus 13-valent pneumococcal conjugate vaccine (PCV13) as a booster dose to broaden and strengthen protection from otitis media (PREVIX_BOOST) in Australian Aboriginal children: study protocol for a randomised controlled trial

INTRODUCTION: Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) are major otitis media pathogens that densely co-colonise the nasopharynx and infect the middle ear of Australian Aboriginal infants from very early in life. Our co-primary hypotheses are that at 18 months of age i...

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Detalles Bibliográficos
Autores principales: Oguoma, Victor M, Wilson, Nicole, Mulholland, Kim, Santosham, Mathuram, Torzillo, Paul, McIntyre, Peter, Smith-Vaughan, Heidi, Balloch, Anne, Chatfield, Mark, Lehmann, Deborah, Binks, Michael J, Chang, Anne, Carapetis, Jonathan, Krause, Vicki, Andrews, Ross, Snelling, Tom, Licciardi, Paul, Morris, Peter, Leach, Amanda Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Infectious Diseases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252982/
https://www.ncbi.nlm.nih.gov/pubmed/32448790
http://dx.doi.org/10.1136/bmjopen-2019-033511

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