Genetic correction of Werner syndrome gene reveals impaired pro‐angiogenic function and HGF insufficiency in mesenchymal stem cells

WRN mutation causes a premature aging disease called Werner syndrome (WS). However, the mechanism by which WRN loss leads to progeroid features evident with impaired tissue repair and regeneration remains unclear. To determine this mechanism, we performed gene editing in reprogrammed induced pluripo...

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Detalles Bibliográficos
Autores principales: Tu, Jiajie, Wan, Chao, Zhang, Fengjie, Cao, Lianbao, Law, Patrick Wai Nok, Tian, Yuyao, Lu, Gang, Rennert, Owen M., Chan, Wai‐Yee, Cheung, Hoi‐Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253065/
https://www.ncbi.nlm.nih.gov/pubmed/32320127
http://dx.doi.org/10.1111/acel.13116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253065/
https://www.ncbi.nlm.nih.gov/pubmed/32320127
http://dx.doi.org/10.1111/acel.13116

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