Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19

Hydroxychloroquine (HCQ) has been used for the treatment of novel coronavirus disease (COVID-19) cases. However, evidence of efficacy remains limited, and adverse events can be associated with its use. Here, we report a case of a patient with severe COVID-19 who, after being administered HCQ, exhibi...

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Autores principales: Falcão, Melissa Barreto, Pamplona de Góes Cavalcanti, Luciano, Filgueiras Filho, Nivaldo Menezes, Antunes de Brito, Carlos Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253107/
https://www.ncbi.nlm.nih.gov/pubmed/32314698
http://dx.doi.org/10.4269/ajtmh.20-0276
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author Falcão, Melissa Barreto
Pamplona de Góes Cavalcanti, Luciano
Filgueiras Filho, Nivaldo Menezes
Antunes de Brito, Carlos Alexandre
author_facet Falcão, Melissa Barreto
Pamplona de Góes Cavalcanti, Luciano
Filgueiras Filho, Nivaldo Menezes
Antunes de Brito, Carlos Alexandre
author_sort Falcão, Melissa Barreto
collection PubMed
description Hydroxychloroquine (HCQ) has been used for the treatment of novel coronavirus disease (COVID-19) cases. However, evidence of efficacy remains limited, and adverse events can be associated with its use. Here, we report a case of a patient with severe COVID-19 who, after being administered HCQ, exhibited a 10-fold increase in serum levels of transaminases, followed by a rapid decrease after HCQ was withdrawn. Considering the significantly increased use of HCQ during the COVID-19 pandemic, this case alerts us to the potential for HCQ to be associated with hepatotoxicity and the need to monitor liver function during HCQ therapy.
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spelling pubmed-72531072020-05-31 Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19 Falcão, Melissa Barreto Pamplona de Góes Cavalcanti, Luciano Filgueiras Filho, Nivaldo Menezes Antunes de Brito, Carlos Alexandre Am J Trop Med Hyg Articles Hydroxychloroquine (HCQ) has been used for the treatment of novel coronavirus disease (COVID-19) cases. However, evidence of efficacy remains limited, and adverse events can be associated with its use. Here, we report a case of a patient with severe COVID-19 who, after being administered HCQ, exhibited a 10-fold increase in serum levels of transaminases, followed by a rapid decrease after HCQ was withdrawn. Considering the significantly increased use of HCQ during the COVID-19 pandemic, this case alerts us to the potential for HCQ to be associated with hepatotoxicity and the need to monitor liver function during HCQ therapy. The American Society of Tropical Medicine and Hygiene 2020-06 2020-04-17 /pmc/articles/PMC7253107/ /pubmed/32314698 http://dx.doi.org/10.4269/ajtmh.20-0276 Text en © The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Falcão, Melissa Barreto
Pamplona de Góes Cavalcanti, Luciano
Filgueiras Filho, Nivaldo Menezes
Antunes de Brito, Carlos Alexandre
Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19
title Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19
title_full Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19
title_fullStr Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19
title_full_unstemmed Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19
title_short Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19
title_sort case report: hepatotoxicity associated with the use of hydroxychloroquine in a patient with covid-19
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253107/
https://www.ncbi.nlm.nih.gov/pubmed/32314698
http://dx.doi.org/10.4269/ajtmh.20-0276
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