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Post-Treatment Surveillance for Lymphatic Filariasis in Plateau and Nasarawa States, Nigeria: Results of Transmission Assessment Surveys

Following the halt of mass drug administration (MDA) for lymphatic filariasis (LF), the WHO recommends at least 4 years of post-treatment surveillance (PTS) to confirm that transmission recrudescence or importation does not occur. The primary means of evaluation during PTS is repeated transmission a...

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Autores principales: Eigege, Abel, Noland, Gregory S., Adelamo, Solomon E., Nwodu, Kenrick, Sallau, Adamu, Umaru, John, Mancha, Bulus S., Davies, Emmanuel, Danboyi, Jacob, Kadimbo, Jonathan A., Saka, Yisa A., Anagbogu, Ifeoma, Miri, Emmanuel S., Richards, Frank O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253131/
https://www.ncbi.nlm.nih.gov/pubmed/32228796
http://dx.doi.org/10.4269/ajtmh.20-0020
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author Eigege, Abel
Noland, Gregory S.
Adelamo, Solomon E.
Nwodu, Kenrick
Sallau, Adamu
Umaru, John
Mancha, Bulus S.
Davies, Emmanuel
Danboyi, Jacob
Kadimbo, Jonathan A.
Saka, Yisa A.
Anagbogu, Ifeoma
Miri, Emmanuel S.
Richards, Frank O.
author_facet Eigege, Abel
Noland, Gregory S.
Adelamo, Solomon E.
Nwodu, Kenrick
Sallau, Adamu
Umaru, John
Mancha, Bulus S.
Davies, Emmanuel
Danboyi, Jacob
Kadimbo, Jonathan A.
Saka, Yisa A.
Anagbogu, Ifeoma
Miri, Emmanuel S.
Richards, Frank O.
author_sort Eigege, Abel
collection PubMed
description Following the halt of mass drug administration (MDA) for lymphatic filariasis (LF), the WHO recommends at least 4 years of post-treatment surveillance (PTS) to confirm that transmission recrudescence or importation does not occur. The primary means of evaluation during PTS is repeated transmission assessment surveys (TASs) conducted at 2- to 3-year intervals after TAS-1 stop-MDA surveys. This study reports the results of TAS-2 and TAS-3 surveys in Plateau and Nasarawa states (pop. 6.9 million) of Nigeria divided into a minimum of seven evaluation units (EUs) per TAS. A total of 26,536 first- and second-year primary school children (approximately 6–7 years old) were tested for circulating filarial antigen (CFA) between 2014 and 2017. Of 12,313 children tested in TAS-2 surveys, only five (0.04%) were CFA positive, with no more than two positive samples from any one EU, which was below the critical value of 20 per EU. Of 14,240 children tested in TAS-3 surveys, none (0%) were CFA positive. These results indicate that LF transmission remains below sustainable transmission levels and suggest that elimination of transmission has been achieved in Plateau and Nasarawa, Nigeria.
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spelling pubmed-72531312020-05-31 Post-Treatment Surveillance for Lymphatic Filariasis in Plateau and Nasarawa States, Nigeria: Results of Transmission Assessment Surveys Eigege, Abel Noland, Gregory S. Adelamo, Solomon E. Nwodu, Kenrick Sallau, Adamu Umaru, John Mancha, Bulus S. Davies, Emmanuel Danboyi, Jacob Kadimbo, Jonathan A. Saka, Yisa A. Anagbogu, Ifeoma Miri, Emmanuel S. Richards, Frank O. Am J Trop Med Hyg Articles Following the halt of mass drug administration (MDA) for lymphatic filariasis (LF), the WHO recommends at least 4 years of post-treatment surveillance (PTS) to confirm that transmission recrudescence or importation does not occur. The primary means of evaluation during PTS is repeated transmission assessment surveys (TASs) conducted at 2- to 3-year intervals after TAS-1 stop-MDA surveys. This study reports the results of TAS-2 and TAS-3 surveys in Plateau and Nasarawa states (pop. 6.9 million) of Nigeria divided into a minimum of seven evaluation units (EUs) per TAS. A total of 26,536 first- and second-year primary school children (approximately 6–7 years old) were tested for circulating filarial antigen (CFA) between 2014 and 2017. Of 12,313 children tested in TAS-2 surveys, only five (0.04%) were CFA positive, with no more than two positive samples from any one EU, which was below the critical value of 20 per EU. Of 14,240 children tested in TAS-3 surveys, none (0%) were CFA positive. These results indicate that LF transmission remains below sustainable transmission levels and suggest that elimination of transmission has been achieved in Plateau and Nasarawa, Nigeria. The American Society of Tropical Medicine and Hygiene 2020-06 2020-03-30 /pmc/articles/PMC7253131/ /pubmed/32228796 http://dx.doi.org/10.4269/ajtmh.20-0020 Text en © The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Eigege, Abel
Noland, Gregory S.
Adelamo, Solomon E.
Nwodu, Kenrick
Sallau, Adamu
Umaru, John
Mancha, Bulus S.
Davies, Emmanuel
Danboyi, Jacob
Kadimbo, Jonathan A.
Saka, Yisa A.
Anagbogu, Ifeoma
Miri, Emmanuel S.
Richards, Frank O.
Post-Treatment Surveillance for Lymphatic Filariasis in Plateau and Nasarawa States, Nigeria: Results of Transmission Assessment Surveys
title Post-Treatment Surveillance for Lymphatic Filariasis in Plateau and Nasarawa States, Nigeria: Results of Transmission Assessment Surveys
title_full Post-Treatment Surveillance for Lymphatic Filariasis in Plateau and Nasarawa States, Nigeria: Results of Transmission Assessment Surveys
title_fullStr Post-Treatment Surveillance for Lymphatic Filariasis in Plateau and Nasarawa States, Nigeria: Results of Transmission Assessment Surveys
title_full_unstemmed Post-Treatment Surveillance for Lymphatic Filariasis in Plateau and Nasarawa States, Nigeria: Results of Transmission Assessment Surveys
title_short Post-Treatment Surveillance for Lymphatic Filariasis in Plateau and Nasarawa States, Nigeria: Results of Transmission Assessment Surveys
title_sort post-treatment surveillance for lymphatic filariasis in plateau and nasarawa states, nigeria: results of transmission assessment surveys
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253131/
https://www.ncbi.nlm.nih.gov/pubmed/32228796
http://dx.doi.org/10.4269/ajtmh.20-0020
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