Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses

ATP-binding cassette (ABC) transporters are molecular pumps ubiquitous across all kingdoms of life. While their structures have been widely reported, the kinetics governing their transport cycles remain largely unexplored. Multidrug resistance protein 1 (MRP1) is an ABC exporter that extrudes a vari...

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Detalles Bibliográficos
Autores principales: Wang, Ling, Johnson, Zachary Lee, Wasserman, Michael R, Levring, Jesper, Chen, Jue, Liu, Shixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253176/
https://www.ncbi.nlm.nih.gov/pubmed/32458799
http://dx.doi.org/10.7554/eLife.56451

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