Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation

Excessive prostaglandin E(2) production is a hallmark of abdominal aortic aneurysm (AAA). Enhanced expression of prostaglandin E(2) receptor EP4 (prostaglandin E receptor 4) in vascular smooth muscle cells (VSMCs) has been demonstrated in human AAAs. Although moderate expression of EP4 contributes t...

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Detalles Bibliográficos
Autores principales: Hiromi, Taro, Yokoyama, Utako, Kurotaki, Daisuke, Mamun, Al, Ishiwata, Ryo, Ichikawa, Yasuhiro, Nishihara, Hiroshi, Umemura, Masanari, Fujita, Takayuki, Yasuda, Shota, Minami, Tomoyuki, Goda, Motohiko, Uchida, Keiji, Suzuki, Shinichi, Takeuchi, Ichiro, Masuda, Munetaka, Breyer, Richard M., Tamura, Tomohiko, Ishikawa, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Translational Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253191/
https://www.ncbi.nlm.nih.gov/pubmed/32321307
http://dx.doi.org/10.1161/ATVBAHA.120.314297

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