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OnabotulinumtoxinA Treatment for Moderate to Severe Forehead Lines: A Review

BACKGROUND: With onabotulinumtoxinA approved for the treatment of glabellar and crow’s feet lines and, most recently, for forehead lines (FHL), it is possible to simultaneously treat multiple areas of the upper face that are of high concern and treatment priority for aesthetically oriented individua...

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Autores principales: De Boulle, Koenraad, Carruthers, Alastair, Solish, Nowell, Carruthers, Jean, Philipp-Dormston, Wolfgang G., Fagien, Steven, Sangha, Sara, Silberberg, Michael, Mao, Cheri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253259/
https://www.ncbi.nlm.nih.gov/pubmed/32537333
http://dx.doi.org/10.1097/GOX.0000000000002669
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author De Boulle, Koenraad
Carruthers, Alastair
Solish, Nowell
Carruthers, Jean
Philipp-Dormston, Wolfgang G.
Fagien, Steven
Sangha, Sara
Silberberg, Michael
Mao, Cheri
author_facet De Boulle, Koenraad
Carruthers, Alastair
Solish, Nowell
Carruthers, Jean
Philipp-Dormston, Wolfgang G.
Fagien, Steven
Sangha, Sara
Silberberg, Michael
Mao, Cheri
author_sort De Boulle, Koenraad
collection PubMed
description BACKGROUND: With onabotulinumtoxinA approved for the treatment of glabellar and crow’s feet lines and, most recently, for forehead lines (FHL), it is possible to simultaneously treat multiple areas of the upper face that are of high concern and treatment priority for aesthetically oriented individuals. This review aims to present key insights on the use of onabotulinumtoxinA for the treatment of moderate to severe FHL. METHODS: Double-blind, placebo-controlled registration trials of onabotulinumtoxinA for the treatment of FHL were included. Using findings from 3 such published studies, we discuss key concepts and clinical experience for the treatment of moderate to severe FHL with onabotulinumtoxinA (20 U in the frontalis and 20 U in the glabellar complex, with/without 24 U in crow’s feet lines), including injection pattern, dose selection, efficacy and safety data, and considerations for patient selection. RESULTS: Across the 2 pivotal phase 3 studies, responder rates on investigator- and subject-assessed measures of appearance of FHL severity were significantly higher with onabotulinumtoxinA versus placebo for the treatment of FHL at day 30 (P < 0.0001), and results were maintained through 3 cycles of onabotulinumtoxinA. CONCLUSIONS: OnabotulinumtoxinA treatment also resulted in high patient satisfaction rates. The incidence of eyebrow and of eyelid ptosis was low, and no new safety signals were detected. OnabotulinumtoxinA is safe and effective and an appropriate option for patients with moderate to severe FHL encountered in clinical practice.
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spelling pubmed-72532592020-06-11 OnabotulinumtoxinA Treatment for Moderate to Severe Forehead Lines: A Review De Boulle, Koenraad Carruthers, Alastair Solish, Nowell Carruthers, Jean Philipp-Dormston, Wolfgang G. Fagien, Steven Sangha, Sara Silberberg, Michael Mao, Cheri Plast Reconstr Surg Glob Open Original Articles BACKGROUND: With onabotulinumtoxinA approved for the treatment of glabellar and crow’s feet lines and, most recently, for forehead lines (FHL), it is possible to simultaneously treat multiple areas of the upper face that are of high concern and treatment priority for aesthetically oriented individuals. This review aims to present key insights on the use of onabotulinumtoxinA for the treatment of moderate to severe FHL. METHODS: Double-blind, placebo-controlled registration trials of onabotulinumtoxinA for the treatment of FHL were included. Using findings from 3 such published studies, we discuss key concepts and clinical experience for the treatment of moderate to severe FHL with onabotulinumtoxinA (20 U in the frontalis and 20 U in the glabellar complex, with/without 24 U in crow’s feet lines), including injection pattern, dose selection, efficacy and safety data, and considerations for patient selection. RESULTS: Across the 2 pivotal phase 3 studies, responder rates on investigator- and subject-assessed measures of appearance of FHL severity were significantly higher with onabotulinumtoxinA versus placebo for the treatment of FHL at day 30 (P < 0.0001), and results were maintained through 3 cycles of onabotulinumtoxinA. CONCLUSIONS: OnabotulinumtoxinA treatment also resulted in high patient satisfaction rates. The incidence of eyebrow and of eyelid ptosis was low, and no new safety signals were detected. OnabotulinumtoxinA is safe and effective and an appropriate option for patients with moderate to severe FHL encountered in clinical practice. Wolters Kluwer Health 2020-03-18 /pmc/articles/PMC7253259/ /pubmed/32537333 http://dx.doi.org/10.1097/GOX.0000000000002669 Text en Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Articles
De Boulle, Koenraad
Carruthers, Alastair
Solish, Nowell
Carruthers, Jean
Philipp-Dormston, Wolfgang G.
Fagien, Steven
Sangha, Sara
Silberberg, Michael
Mao, Cheri
OnabotulinumtoxinA Treatment for Moderate to Severe Forehead Lines: A Review
title OnabotulinumtoxinA Treatment for Moderate to Severe Forehead Lines: A Review
title_full OnabotulinumtoxinA Treatment for Moderate to Severe Forehead Lines: A Review
title_fullStr OnabotulinumtoxinA Treatment for Moderate to Severe Forehead Lines: A Review
title_full_unstemmed OnabotulinumtoxinA Treatment for Moderate to Severe Forehead Lines: A Review
title_short OnabotulinumtoxinA Treatment for Moderate to Severe Forehead Lines: A Review
title_sort onabotulinumtoxina treatment for moderate to severe forehead lines: a review
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253259/
https://www.ncbi.nlm.nih.gov/pubmed/32537333
http://dx.doi.org/10.1097/GOX.0000000000002669
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