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Keloids: Which Types Can Be Excised without Risk of Recurrence? A New Clinical Classification

A surgical team from Interplast-Germany removed 387 keloids in 302 patients during 4 visits to Goma, Democratic Republic of the Congo, from 2015-2018. Preoperative and postoperative photographs and a thorough anamnesis of keloids were done for all patients. In addition, 18 selected biopsies from 4 t...

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Autores principales: Lemperle, Gottfried, Schierle, Johannes, Kitoga, Kakubindi Eric, Kassem-Trautmann, Katja, Sachs, Christoph, Dimmler, Arno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253266/
https://www.ncbi.nlm.nih.gov/pubmed/32537319
http://dx.doi.org/10.1097/GOX.0000000000002582
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author Lemperle, Gottfried
Schierle, Johannes
Kitoga, Kakubindi Eric
Kassem-Trautmann, Katja
Sachs, Christoph
Dimmler, Arno
author_facet Lemperle, Gottfried
Schierle, Johannes
Kitoga, Kakubindi Eric
Kassem-Trautmann, Katja
Sachs, Christoph
Dimmler, Arno
author_sort Lemperle, Gottfried
collection PubMed
description A surgical team from Interplast-Germany removed 387 keloids in 302 patients during 4 visits to Goma, Democratic Republic of the Congo, from 2015-2018. Preoperative and postoperative photographs and a thorough anamnesis of keloids were done for all patients. In addition, 18 selected biopsies from 4 types of keloids were histologically examined in Germany. METHODS: Treatment options were tested and keloid recurrence rates were compared with data from questionnaires, photographs, and histology. RESULTS: Keloids were classified accordingly as follows: (1) fresh nodular (continuously growing) keloids had a 30% recurrence rate after surgery: no common adjuvant therapy but triamcinolone acetonide (TAC) injections on onset, only; (a) earlobe keloids had the lowest recurrence rate after complete excision with negative resection margins; (2) superficial spreading (or butterfly) keloids were treated with TAC injections only; (3) mature (nongrowing or burned-out) keloids had also a low recurrence rate of 4.5%, which were then treated with TAC on onset, only; and (4) multiple keloids comprise various types in different stages. CONCLUSIONS: According to this classification, about 50% of keloids may be removed surgically without risk of recurrence in the examined patient population in Africa, where only TAC injections, but no radiation, are available. Adjuvant TAC or radiation should be started at the onset of recurrence and not generally.
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spelling pubmed-72532662020-06-11 Keloids: Which Types Can Be Excised without Risk of Recurrence? A New Clinical Classification Lemperle, Gottfried Schierle, Johannes Kitoga, Kakubindi Eric Kassem-Trautmann, Katja Sachs, Christoph Dimmler, Arno Plast Reconstr Surg Glob Open Original Articles A surgical team from Interplast-Germany removed 387 keloids in 302 patients during 4 visits to Goma, Democratic Republic of the Congo, from 2015-2018. Preoperative and postoperative photographs and a thorough anamnesis of keloids were done for all patients. In addition, 18 selected biopsies from 4 types of keloids were histologically examined in Germany. METHODS: Treatment options were tested and keloid recurrence rates were compared with data from questionnaires, photographs, and histology. RESULTS: Keloids were classified accordingly as follows: (1) fresh nodular (continuously growing) keloids had a 30% recurrence rate after surgery: no common adjuvant therapy but triamcinolone acetonide (TAC) injections on onset, only; (a) earlobe keloids had the lowest recurrence rate after complete excision with negative resection margins; (2) superficial spreading (or butterfly) keloids were treated with TAC injections only; (3) mature (nongrowing or burned-out) keloids had also a low recurrence rate of 4.5%, which were then treated with TAC on onset, only; and (4) multiple keloids comprise various types in different stages. CONCLUSIONS: According to this classification, about 50% of keloids may be removed surgically without risk of recurrence in the examined patient population in Africa, where only TAC injections, but no radiation, are available. Adjuvant TAC or radiation should be started at the onset of recurrence and not generally. Wolters Kluwer Health 2020-03-27 /pmc/articles/PMC7253266/ /pubmed/32537319 http://dx.doi.org/10.1097/GOX.0000000000002582 Text en Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Articles
Lemperle, Gottfried
Schierle, Johannes
Kitoga, Kakubindi Eric
Kassem-Trautmann, Katja
Sachs, Christoph
Dimmler, Arno
Keloids: Which Types Can Be Excised without Risk of Recurrence? A New Clinical Classification
title Keloids: Which Types Can Be Excised without Risk of Recurrence? A New Clinical Classification
title_full Keloids: Which Types Can Be Excised without Risk of Recurrence? A New Clinical Classification
title_fullStr Keloids: Which Types Can Be Excised without Risk of Recurrence? A New Clinical Classification
title_full_unstemmed Keloids: Which Types Can Be Excised without Risk of Recurrence? A New Clinical Classification
title_short Keloids: Which Types Can Be Excised without Risk of Recurrence? A New Clinical Classification
title_sort keloids: which types can be excised without risk of recurrence? a new clinical classification
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253266/
https://www.ncbi.nlm.nih.gov/pubmed/32537319
http://dx.doi.org/10.1097/GOX.0000000000002582
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