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Anterior temporal lobe is necessary for efficient lateralised processing of spoken word identity

In the healthy human brain, the processing of language is strongly lateralised, usually to the left hemisphere, while the processing of complex non-linguistic sounds recruits brain regions bilaterally. Here we asked whether the anterior temporal lobes, strongly implicated in semantic processing, are...

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Autores principales: Cope, Thomas E., Shtyrov, Yury, MacGregor, Lucy J., Holland, Rachel, Pulvermüller, Friedemann, Rowe, James B., Patterson, Karalyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253293/
https://www.ncbi.nlm.nih.gov/pubmed/32065956
http://dx.doi.org/10.1016/j.cortex.2019.12.025
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author Cope, Thomas E.
Shtyrov, Yury
MacGregor, Lucy J.
Holland, Rachel
Pulvermüller, Friedemann
Rowe, James B.
Patterson, Karalyn
author_facet Cope, Thomas E.
Shtyrov, Yury
MacGregor, Lucy J.
Holland, Rachel
Pulvermüller, Friedemann
Rowe, James B.
Patterson, Karalyn
author_sort Cope, Thomas E.
collection PubMed
description In the healthy human brain, the processing of language is strongly lateralised, usually to the left hemisphere, while the processing of complex non-linguistic sounds recruits brain regions bilaterally. Here we asked whether the anterior temporal lobes, strongly implicated in semantic processing, are critical to this special treatment of spoken words. Nine patients with semantic dementia (SD) and fourteen age-matched controls underwent magnetoencephalography and structural MRI. Voxel based morphometry demonstrated the stereotypical pattern of SD: severe grey matter loss restricted to the anterior temporal lobes, with the left side more affected. During magnetoencephalography, participants listened to word sets in which identity and meaning were ambiguous until word completion, for example PLAYED versus PLATE. Whereas left-hemispheric responses were similar across groups, patients demonstrated increased right hemisphere activity 174–294 msec after stimulus disambiguation. Source reconstructions confirmed recruitment of right-sided analogues of language regions in SD: atrophy of anterior temporal lobes was associated with increased activity in right temporal pole, middle temporal gyrus, inferior frontal gyrus and supramarginal gyrus. Overall, the results indicate that anterior temporal lobes are necessary for normal and efficient lateralised processing of word identity by the language network.
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spelling pubmed-72532932020-11-01 Anterior temporal lobe is necessary for efficient lateralised processing of spoken word identity Cope, Thomas E. Shtyrov, Yury MacGregor, Lucy J. Holland, Rachel Pulvermüller, Friedemann Rowe, James B. Patterson, Karalyn Cortex Article In the healthy human brain, the processing of language is strongly lateralised, usually to the left hemisphere, while the processing of complex non-linguistic sounds recruits brain regions bilaterally. Here we asked whether the anterior temporal lobes, strongly implicated in semantic processing, are critical to this special treatment of spoken words. Nine patients with semantic dementia (SD) and fourteen age-matched controls underwent magnetoencephalography and structural MRI. Voxel based morphometry demonstrated the stereotypical pattern of SD: severe grey matter loss restricted to the anterior temporal lobes, with the left side more affected. During magnetoencephalography, participants listened to word sets in which identity and meaning were ambiguous until word completion, for example PLAYED versus PLATE. Whereas left-hemispheric responses were similar across groups, patients demonstrated increased right hemisphere activity 174–294 msec after stimulus disambiguation. Source reconstructions confirmed recruitment of right-sided analogues of language regions in SD: atrophy of anterior temporal lobes was associated with increased activity in right temporal pole, middle temporal gyrus, inferior frontal gyrus and supramarginal gyrus. Overall, the results indicate that anterior temporal lobes are necessary for normal and efficient lateralised processing of word identity by the language network. 2020-05-01 2020-01-24 /pmc/articles/PMC7253293/ /pubmed/32065956 http://dx.doi.org/10.1016/j.cortex.2019.12.025 Text en https://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cope, Thomas E.
Shtyrov, Yury
MacGregor, Lucy J.
Holland, Rachel
Pulvermüller, Friedemann
Rowe, James B.
Patterson, Karalyn
Anterior temporal lobe is necessary for efficient lateralised processing of spoken word identity
title Anterior temporal lobe is necessary for efficient lateralised processing of spoken word identity
title_full Anterior temporal lobe is necessary for efficient lateralised processing of spoken word identity
title_fullStr Anterior temporal lobe is necessary for efficient lateralised processing of spoken word identity
title_full_unstemmed Anterior temporal lobe is necessary for efficient lateralised processing of spoken word identity
title_short Anterior temporal lobe is necessary for efficient lateralised processing of spoken word identity
title_sort anterior temporal lobe is necessary for efficient lateralised processing of spoken word identity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253293/
https://www.ncbi.nlm.nih.gov/pubmed/32065956
http://dx.doi.org/10.1016/j.cortex.2019.12.025
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