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Quassinoid analogs with enhanced efficacy for treatment of hematologic malignancies target the PI3Kγ isoform
Development of novel PI3K inhibitors is an important strategy to overcome their resistance and poor tolerability in clinical trials. The quassinoid family member Brusatol shows specific inhibitory activity against hematologic malignancies. However, the mechanism of its anti-cancer activity is unknow...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253423/ https://www.ncbi.nlm.nih.gov/pubmed/32461675 http://dx.doi.org/10.1038/s42003-020-0996-z |