A Comprehensive Transcriptome Analysis Identifies FXN and BDNF as Novel Targets of miRNAs in Friedreich’s Ataxia Patients

Friedreich’s ataxia (FRDA) is a genetic neurodegenerative disease that is caused by guanine-adenine-adenine (GAA) nucleotide repeat expansions in the first intron of the frataxin (FXN) gene. Although present in the intron, this mutation leads to a substantial decrease in protein expression. Currentl...

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Detalles Bibliográficos
Autores principales: Misiorek, Julia O., Schreiber, Anna M., Urbanek-Trzeciak, Martyna O., Jazurek-Ciesiołka, Magdalena, Hauser, Lauren A., Lynch, David R., Napierala, Jill S., Napierala, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253519/
https://www.ncbi.nlm.nih.gov/pubmed/32291635
http://dx.doi.org/10.1007/s12035-020-01899-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253519/
https://www.ncbi.nlm.nih.gov/pubmed/32291635
http://dx.doi.org/10.1007/s12035-020-01899-1

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