Adrenergic Signaling-Induced Ultrastructural Strengthening of Intercalated Discs via Plakoglobin Is Crucial for Positive Adhesiotropy in Murine Cardiomyocytes

Intercalated discs (ICDs), which connect adjacent cardiomyocytes, are composed of desmosomes, adherens junctions (AJs) and gap junctions (GJs). Previous data demonstrated that adrenergic signaling enhances cardiac myocyte cohesion, referred to as positive adhesiotropy, via PKA-mediated phosphorylati...

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Detalles Bibliográficos
Autores principales: Yeruva, Sunil, Kempf, Ellen, Egu, Desalegn Tadesse, Flaswinkel, Heinrich, Kugelmann, Daniela, Waschke, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253624/
https://www.ncbi.nlm.nih.gov/pubmed/32508670
http://dx.doi.org/10.3389/fphys.2020.00430

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