Vitamin D Supplementation Rescues Aberrant NF-κB Pathway Activation and Partially Ameliorates Rett Syndrome Phenotypes in Mecp2 Mutant Mice

Rett syndrome (RTT) is a severe, progressive X-linked neurodevelopmental disorder caused by mutations in the transcriptional regulator MECP2. We previously identified aberrant NF-κB pathway upregulation in brains of Mecp2-null mice and demonstrated that genetically attenuating NF-κB rescues some cha...

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Detalles Bibliográficos
Autores principales: Ribeiro, Mayara C., Moore, Seth M., Kishi, Noriyuki, Macklis, Jeffrey D., MacDonald, Jessica L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2020
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253640/
https://www.ncbi.nlm.nih.gov/pubmed/32393583
http://dx.doi.org/10.1523/ENEURO.0167-20.2020

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