Cargando…

Ginsenoside Re Attenuates High Glucose-Induced RF/6A Injury via Regulating PI3K/AKT Inhibited HIF-1α/VEGF Signaling Pathway

Hyperglycaemia-induced retinal microvascular endothelial cell apoptosis is a critical and principle event in diabetic retinopathy (DR), which involves a series of complex processes such as mitochondrial dysfunction and oxidative stress. Ginsenoside Re (Re), a key ingredients of ginseng, is considere...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Weijie, Zhou, Ping, Qu, Muwen, Dai, Ziru, Zhang, Xuelian, Zhang, Chenyang, Dong, Xi, Sun, Guibo, Sun, Xiaobo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253708/ https://www.ncbi.nlm.nih.gov/pubmed/32528282 http://dx.doi.org/10.3389/fphar.2020.00695

Ejemplares similares

Corrigendum: Ginsenoside Re Attenuates High Glucose-Induced RF/6A Injury via Regulating PI3K/AKT Inhibited HIF-1a/VEGF Signaling Pathway
por: Xie, Weijie, et al.
Publicado: (2020)

Ginsenoside Rb1 Protects Against Diabetic Cardiomyopathy by Regulating the Adipocytokine Pathway
por: Zhang, Chenyang, et al.
Publicado: (2022)

Inhibitory Effects of Ginsenoside Rb1 on Early Atherosclerosis in ApoE-/- Mice via Inhibition of Apoptosis and Enhancing Autophagy
por: Zhou, Ping, et al.
Publicado: (2018)

Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies
por: Xie, Weijie, et al.
Publicado: (2018)

Protective Effects of Total Saponins of Aralia elata (Miq.) on Endothelial Cell Injury Induced by TNF-α via Modulation of the PI3K/Akt and NF-κB Signalling Pathways
por: Zhou, Ping, et al.
Publicado: (2018)

Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis
por: Zhou, Ping, et al.
Publicado: (2019)

Ginsenoside Re Treatment Attenuates Myocardial Hypoxia/Reoxygenation Injury by Inhibiting HIF-1α Ubiquitination
por: Sun, Huiyuan, et al.
Publicado: (2020)

Effect of Panax notoginseng Saponins and Major Anti-Obesity Components on Weight Loss
por: Zhang, Xuelian, et al.
Publicado: (2021)

Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes
por: Zhang, Chenyang, et al.
Publicado: (2020)

Current Progress in Delineating the Roles of Pseudokinase TRIB1 in Controlling Human Diseases
por: Zhang, Xuelian, et al.
Publicado: (2021)

Trib1 deficiency causes brown adipose respiratory chain depletion and mitochondrial disorder
por: Zhang, Xuelian, et al.
Publicado: (2021)

Salvianolic Acid B and Ginsenoside Re Synergistically Protect Against Ox-LDL-Induced Endothelial Apoptosis Through the Antioxidative and Antiinflammatory Mechanisms
por: Yang, Ke, et al.
Publicado: (2018)

Notoginsenoside R1 Protects db/db Mice against Diabetic Nephropathy via Upregulation of Nrf2-Mediated HO-1 Expression
por: Zhang, Bin, et al.
Publicado: (2019)

Panax notoginseng Saponin Protects Against Diabetic Cardiomyopathy Through Lipid Metabolism Modulation
por: Zhang, Chenyang, et al.
Publicado: (2022)

Isorhamnetin Attenuates Atherosclerosis by Inhibiting Macrophage Apoptosis via PI3K/AKT Activation and HO-1 Induction
por: Luo, Yun, et al.
Publicado: (2015)

Atorvastatin promotes AMPK signaling to protect against high fat diet-induced non-alcoholic fatty liver in golden hamsters
por: Zhang, Bin, et al.
Publicado: (2020)

An In Silico Model for Predicting Drug-Induced Hepatotoxicity
por: He, Shuaibing, et al.
Publicado: (2019)

Effects of Platycodin D on Proliferation, Apoptosis and PI3K/Akt Signal Pathway of Human Glioma U251 Cells
por: Xu, Chong, et al.
Publicado: (2014)

Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway
por: Sun, Jing, et al.
Publicado: (2013)

Re-evaluation of physicochemical and NMR data of triol ginsenosides Re, Rf, Rg2, and 20-gluco-Rf from Panax ginseng roots
por: Cho, Jin-Gyeong, et al.
Publicado: (2013)

The effects of Ginsenosides on PI3K/AKT signaling pathway
por: Ghafouri-Fard, Soudeh, et al.
Publicado: (2022)

Gypenoside XVII Prevents Atherosclerosis by Attenuating Endothelial Apoptosis and Oxidative Stress: Insight into the ERα-Mediated PI3K/Akt Pathway
por: Yang, Ke, et al.
Publicado: (2017)

Notoginsenoside R1 Protects Against Diabetic Cardiomyopathy Through Activating Estrogen Receptor α and Its Downstream Signaling
por: Zhang, Bin, et al.
Publicado: (2018)

Herb-Induced Liver Injury: Phylogenetic Relationship, Structure-Toxicity Relationship, and Herb-Ingredient Network Analysis
por: He, Shuaibing, et al.
Publicado: (2019)

Ginsenoside compound K inhibits the proliferation, migration and invasion of Eca109 cell via VEGF-A/Pi3k/Akt pathway
por: Huang, Jianhou, et al.
Publicado: (2022)

Ginsenoside Compound K Attenuates Ox-LDL-Mediated Macrophage Inflammation and Foam Cell Formation via Autophagy Induction and Modulating NF-κB, p38, and JNK MAPK Signaling
por: Lu, Shan, et al.
Publicado: (2020)

Biotransformation of Ginsenoside Rf to Rh(1) by Recombinant β-Glucosidase
por: Ruan, Chang-Chun, et al.
Publicado: (2009)

Notoginsenoside R1 Improves Cerebral Ischemia/Reperfusion Injury by Promoting Neurogenesis via the BDNF/Akt/CREB Pathway
por: Zhu, Ting, et al.
Publicado: (2021)

Interspecies Variation in NCMN-O-Demethylation in Liver Microsomes from Various Species
por: Dai, Ziru, et al.
Publicado: (2019)

Pharmacological Properties of Ginsenoside Re
por: Gao, Xiao-Yan, et al.
Publicado: (2022)

Notoginsenoside R1 Ameliorates Diabetic Retinopathy through PINK1-Dependent Activation of Mitophagy
por: Zhou, Ping, et al.
Publicado: (2019)

Correction: Zhou, P., et al. Notoginsenoside R1 Ameliorates Diabetic Retinopathy through PINK1-Dependent Activation of Mitophagy. Cells, 2019, 8, 213
por: Zhou, Ping, et al.
Publicado: (2020)

Down-regulation of HIF-1α inhibits the proliferation, migration, and invasion of gastric cancer by inhibiting PI3K/AKT pathway and VEGF expression
por: Zhang, Jingjing, et al.
Publicado: (2018)

Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics
por: Peng, Dacheng, et al.
Publicado: (2012)

Ginsenoside Rg1 prevents early diabetic retinopathy via reducing retinal ganglion cell layer and inner nuclear layer cell apoptosis in db/db mice
por: Gao, Ye, et al.
Publicado: (2020)

Calenduloside E suppresses calcium overload by promoting the interaction between L-type calcium channels and Bcl2-associated athanogene 3 to alleviate myocardial ischemia/reperfusion injury
por: Wang, Ruiying, et al.
Publicado: (2020)

Adiponectin promotes VEGF-A-dependent angiogenesis in human chondrosarcoma through PI3K, Akt, mTOR, and HIF-α pathway
por: Lee, Hsiang-Ping, et al.
Publicado: (2015)

Attenuation of TNF-α-Induced Inflammatory Injury in Endothelial Cells by Ginsenoside Rb1 via Inhibiting NF-κB, JNK and p38 Signaling Pathways
por: Zhou, Ping, et al.
Publicado: (2017)

PI3K/Akt and HIF-1 signaling pathway in hypoxia-ischemia
por: Zhang, Zhen, et al.
Publicado: (2018)

Design and synthesis of acetaminophen probe APAP-P1 for identification of the toxicity targets thioredoxin reductase-1 in HepaRG cells
por: Wang, Shan, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_n6h745u5v11ahiga5u03fd5414