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Identification of the Biosynthetic Gene Cluster of Thermoactinoamides and Discovery of New Congeners by Integrated Genome Mining and MS-Based Molecular Networking

The putative non-ribosomal peptide synthetase (NRPS) gene cluster encoding the biosynthesis of the bioactive cyclohexapeptide thermoactinoamide A (1) was identified in Thermoactinomyces vulgaris DSM 43016. Based on an in silico prediction, the biosynthetic operon was shown to contain two trimodular...

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Detalles Bibliográficos
Autores principales:	Della Sala, Gerardo, Mangoni, Alfonso, Costantino, Valeria, Teta, Roberta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253712/ https://www.ncbi.nlm.nih.gov/pubmed/32528927 http://dx.doi.org/10.3389/fchem.2020.00397

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