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Cinacalcet use in pediatric chronic kidney disease: A survey study
OBJECTIVES: To evaluate the practice and attitude of pediatrics nephrologists about cinacalcet use in children. METHODS: An electronic structured questionnaire was answered by pediatric nephrologists practicing in the Kingdom of Saudi Arabia (KSA) and Gulf Council countries (GCC). RESULTS: A total o...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Saudi Medical Journal
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253826/ https://www.ncbi.nlm.nih.gov/pubmed/32373914 http://dx.doi.org/10.15537/smj.2020.5.25072 |
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author | Al-Ahmed, Rafif A. Sheerah, Areej A. Alhasan, Khalid A. Kari, Jameela A. |
author_facet | Al-Ahmed, Rafif A. Sheerah, Areej A. Alhasan, Khalid A. Kari, Jameela A. |
author_sort | Al-Ahmed, Rafif A. |
collection | PubMed |
description | OBJECTIVES: To evaluate the practice and attitude of pediatrics nephrologists about cinacalcet use in children. METHODS: An electronic structured questionnaire was answered by pediatric nephrologists practicing in the Kingdom of Saudi Arabia (KSA) and Gulf Council countries (GCC). RESULTS: A total of 42 pediatric nephrologists responded, of them, 42% used cinacalcet for young children ≤5 years of age and 79% used for children. There were wide variations in the method of administration (examples: crushed, divided, whole tablets), monitoring, doses and response definition, and follow-up. No serious complications after starting cinacalcet was observed in 50%, while 40% reported various complications, mainly hypocalcemia (70%). Cinacalcet was stopped without achieving the target parathyroid hormone in more than half (55%) of children because of intractable adverse effects (40%), poor response (30%), non-adherence (25%), or high cost (5%). CONCLUSION: Cinacalcet is used by the majority of pediatric nephrologists in KSA and GCC. A standard clinical guideline is needed to be followed by all users. |
format | Online Article Text |
id | pubmed-7253826 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Saudi Medical Journal |
record_format | MEDLINE/PubMed |
spelling | pubmed-72538262021-03-05 Cinacalcet use in pediatric chronic kidney disease: A survey study Al-Ahmed, Rafif A. Sheerah, Areej A. Alhasan, Khalid A. Kari, Jameela A. Saudi Med J Original Article OBJECTIVES: To evaluate the practice and attitude of pediatrics nephrologists about cinacalcet use in children. METHODS: An electronic structured questionnaire was answered by pediatric nephrologists practicing in the Kingdom of Saudi Arabia (KSA) and Gulf Council countries (GCC). RESULTS: A total of 42 pediatric nephrologists responded, of them, 42% used cinacalcet for young children ≤5 years of age and 79% used for children. There were wide variations in the method of administration (examples: crushed, divided, whole tablets), monitoring, doses and response definition, and follow-up. No serious complications after starting cinacalcet was observed in 50%, while 40% reported various complications, mainly hypocalcemia (70%). Cinacalcet was stopped without achieving the target parathyroid hormone in more than half (55%) of children because of intractable adverse effects (40%), poor response (30%), non-adherence (25%), or high cost (5%). CONCLUSION: Cinacalcet is used by the majority of pediatric nephrologists in KSA and GCC. A standard clinical guideline is needed to be followed by all users. Saudi Medical Journal 2020-05 /pmc/articles/PMC7253826/ /pubmed/32373914 http://dx.doi.org/10.15537/smj.2020.5.25072 Text en Copyright: © Saudi Medical Journal http://creativecommons.org/licenses/by-nc This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Al-Ahmed, Rafif A. Sheerah, Areej A. Alhasan, Khalid A. Kari, Jameela A. Cinacalcet use in pediatric chronic kidney disease: A survey study |
title | Cinacalcet use in pediatric chronic kidney disease: A survey study |
title_full | Cinacalcet use in pediatric chronic kidney disease: A survey study |
title_fullStr | Cinacalcet use in pediatric chronic kidney disease: A survey study |
title_full_unstemmed | Cinacalcet use in pediatric chronic kidney disease: A survey study |
title_short | Cinacalcet use in pediatric chronic kidney disease: A survey study |
title_sort | cinacalcet use in pediatric chronic kidney disease: a survey study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253826/ https://www.ncbi.nlm.nih.gov/pubmed/32373914 http://dx.doi.org/10.15537/smj.2020.5.25072 |
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