Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2

Testicular dysfunction due to hyperglycemia is the main cause of infertility in diabetic men. Over the years, in order to solve this growing problem, a lot of research has been done and a variety of treatments have been created, but so far, there is no safe, effective, and practical method to preven...

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Detalles Bibliográficos
Autores principales: Tian, Yuanyuan, Song, Wei, Xu, Dongsheng, Chen, Xiao, Li, Xiaojiao, Zhao, Yuguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254092/
https://www.ncbi.nlm.nih.gov/pubmed/32509151
http://dx.doi.org/10.1155/2020/7156579
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author Tian, Yuanyuan
Song, Wei
Xu, Dongsheng
Chen, Xiao
Li, Xiaojiao
Zhao, Yuguang
author_facet Tian, Yuanyuan
Song, Wei
Xu, Dongsheng
Chen, Xiao
Li, Xiaojiao
Zhao, Yuguang
author_sort Tian, Yuanyuan
collection PubMed
description Testicular dysfunction due to hyperglycemia is the main cause of infertility in diabetic men. Over the years, in order to solve this growing problem, a lot of research has been done and a variety of treatments have been created, but so far, there is no safe, effective, and practical method to prevent male infertility caused by diabetes. In this review, we emphasize the male infertility mechanism caused by diabetes from the effects of oxidative stress and autophagy on the function of testes via the PI3K/Akt/mTOR signaling pathway, and we highlight that oxidative stress-induced autophagy breaks the feedforward loop linking Nrf2 and p62 and promotes oxidative damage in diabetic testes.
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spelling pubmed-72540922020-06-06 Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2 Tian, Yuanyuan Song, Wei Xu, Dongsheng Chen, Xiao Li, Xiaojiao Zhao, Yuguang Oxid Med Cell Longev Review Article Testicular dysfunction due to hyperglycemia is the main cause of infertility in diabetic men. Over the years, in order to solve this growing problem, a lot of research has been done and a variety of treatments have been created, but so far, there is no safe, effective, and practical method to prevent male infertility caused by diabetes. In this review, we emphasize the male infertility mechanism caused by diabetes from the effects of oxidative stress and autophagy on the function of testes via the PI3K/Akt/mTOR signaling pathway, and we highlight that oxidative stress-induced autophagy breaks the feedforward loop linking Nrf2 and p62 and promotes oxidative damage in diabetic testes. Hindawi 2020-05-18 /pmc/articles/PMC7254092/ /pubmed/32509151 http://dx.doi.org/10.1155/2020/7156579 Text en Copyright © 2020 Yuanyuan Tian et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tian, Yuanyuan
Song, Wei
Xu, Dongsheng
Chen, Xiao
Li, Xiaojiao
Zhao, Yuguang
Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2
title Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2
title_full Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2
title_fullStr Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2
title_full_unstemmed Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2
title_short Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2
title_sort autophagy induced by ros aggravates testis oxidative damage in diabetes via breaking the feedforward loop linking p62 and nrf2
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254092/
https://www.ncbi.nlm.nih.gov/pubmed/32509151
http://dx.doi.org/10.1155/2020/7156579
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