Cargando…

Endogenous TLR2 ligand embedded in the catalytic region of human cysteinyl-tRNA synthetase 1

BACKGROUND: The generation of antigen-specific cytotoxic T lymphocyte (CTL) responses is required for successful cancer vaccine therapy. In this regard, ligands of Toll-like receptors (TLRs) have been suggested to activate adaptive immune responses by modulating the function of antigen-presenting ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cho, Seongmin, Kim, Sang Bum, Lee, Youngjin, Song, Ee Chan, Kim, Uijoo, Kim, Hyeong Yun, Suh, Ji Hun, Goughnour, Peter C, Kim, YounHa, Yoon, Ina, Shin, Na Young, Kim, Doyeun, Kim, Il-Kyu, Kang, Chang-Yuil, Jang, Song Yee, Kim, Myung Hee, Kim, Sunghoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254149/ https://www.ncbi.nlm.nih.gov/pubmed/32461342 http://dx.doi.org/10.1136/jitc-2019-000277

Ejemplares similares

Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells
por: Kim, Sang Bum, et al.
Publicado: (2017)

Exosomal secretion of truncated cytosolic lysyl-tRNA synthetase induces inflammation during cell starvation
por: Kim, Sang Bum, et al.
Publicado: (2018)

Extracellular vesicles derived from macrophages display glycyl‐tRNA synthetase 1 and exhibit anti‐cancer activity
por: Goughnour, Peter C., et al.
Publicado: (2020)

Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration
por: Jeong, Seung Jae, et al.
Publicado: (2018)

Functional and pathologic association of aminoacyl-tRNA synthetases with cancer
por: Sung, Yulseung, et al.
Publicado: (2022)

A threonyl-tRNA synthetase-mediated translation initiation machinery
por: Jeong, Seung Jae, et al.
Publicado: (2019)

Structural basis for the dynamics of human methionyl-tRNA synthetase in multi-tRNA synthetase complexes
por: Kim, Dong Kyu, et al.
Publicado: (2021)

Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex
por: Kim, Kyung Rok, et al.
Publicado: (2013)

Aminoacyl-tRNA synthetases, therapeutic targets for infectious diseases
por: Lee, Eun-Young, et al.
Publicado: (2018)

Glutamyl-Prolyl-tRNA Synthetase Regulates Epithelial Expression of Mesenchymal Markers and Extracellular Matrix Proteins: Implications for Idiopathic Pulmonary Fibrosis
por: Song, Dae-Geun, et al.
Publicado: (2018)

Essentiality Assessment of Cysteinyl and Lysyl-tRNA Synthetases of Mycobacterium smegmatis
por: Ravishankar, Sudha, et al.
Publicado: (2016)

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics
por: Akaike, Takaaki, et al.
Publicado: (2017)

Protocol for improving diffraction quality of leucyl-tRNA synthetase 1 with methylation and post-crystallization soaking and cooling in cryoprotectants
por: Kim, Sulhee, et al.
Publicado: (2021)

Plasma Lysyl-tRNA Synthetase 1 (KARS1) as a Novel Diagnostic and Monitoring Biomarker for Colorectal Cancer
por: Suh, Ji Hun, et al.
Publicado: (2020)

Cancer Association Study of Aminoacyl-tRNA Synthetase Signaling Network in Glioblastoma
por: Kim, Yong-Wan, et al.
Publicado: (2012)

Nucleolar Localization of Human Methionyl–Trna Synthetase and Its Role in Ribosomal RNA Synthesis
por: Ko, Young-Gyu, et al.
Publicado: (2000)

The DRS–AIMP2–EPRS subcomplex acts as a pivot in the multi-tRNA synthetase complex
por: Hahn, Hyunggu, et al.
Publicado: (2019)

Tryptophanyl-tRNA Synthetase 1 Signals Activate TREM-1 via TLR2 and TLR4
por: Nguyen, Tram T. T., et al.
Publicado: (2020)

Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels
por: Nam, Seo Hee, et al.
Publicado: (2015)

Erratum: Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels
por: Nam, Seo Hee, et al.
Publicado: (2016)

Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl‐tRNA synthetase 1
por: Yoon, Ina, et al.
Publicado: (2023)

Methionyl-tRNA Synthetase is a Useful Diagnostic Marker for Lymph Node Metastasis in Non-Small Cell Lung Cancer
por: Lee, Jung Mo, et al.
Publicado: (2019)

Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with cancer
por: Lee, Ji-Hyun, et al.
Publicado: (2015)

Ultra-thin membrane filter with a uniformly arrayed nanopore structure for nanoscale separation of extracellular vesicles without cake formation
por: Kim, Daesan, et al.
Publicado: (2022)

Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling
por: Lee, Eun-Young, et al.
Publicado: (2022)

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
por: Hayano, M, et al.
Publicado: (2016)

O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine
por: Kim, Kibum, et al.
Publicado: (2022)

Promiscuous methionyl-tRNA synthetase mediates adaptive mistranslation to protect cells against oxidative stress
por: Lee, Jin Young, et al.
Publicado: (2014)

Cysteinyl-tRNA Synthetase 1 Promotes Ferroptosis-Induced Cell Death via Regulating GPX4 Expression
por: Zhang, Wanfei, et al.
Publicado: (2022)

Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase
por: Fang, Pengfei, et al.
Publicado: (2015)

Recent Development of Aminoacyl-tRNA Synthetase Inhibitors for Human Diseases: A Future Perspective
por: Kim, Soong-Hyun, et al.
Publicado: (2020)

Author Correction: O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine
por: Kim, Kibum, et al.
Publicado: (2022)

Aminoacyl-tRNA synthetase evolution and sectoring of the genetic code
por: Pak, Daewoo, et al.
Publicado: (2018)

Tryptophanyl-tRNA Synthetase as a Potential Therapeutic Target
por: Ahn, Young Ha, et al.
Publicado: (2021)

A tRNA- and Anticodon-Centric View of the Evolution of Aminoacyl-tRNA Synthetases, tRNAomes, and the Genetic Code
por: Kim, Yunsoo, et al.
Publicado: (2019)

Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1
por: Chung, Scisung, et al.
Publicado: (2022)

β-Turn mimetic-based stabilizers of protein–protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase
por: Kim, Chanwoo, et al.
Publicado: (2016)

Methionyl-tRNA synthetase overexpression is associated with poor clinical outcomes in non-small cell lung cancer
por: Kim, Eun Young, et al.
Publicado: (2017)

Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
por: Kim, Jong Hyun, et al.
Publicado: (2017)

Structural Basis for the Antibiotic Resistance of Eukaryotic Isoleucyl-tRNA Synthetase
por: Chung, Scisung, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_krviu7e376s4o178c0dfp1i8bs