Neoantigen load and HLA-class I expression identify a subgroup of tumors with a T-cell-inflamed phenotype and favorable prognosis in homologous recombination-proficient high-grade serous ovarian carcinoma

BACKGROUND: There is increasing evidence for the benefit of poly ADP ribose polymerase (PARP) inhibitors in a subset of high-grade serous ovarian carcinoma (HGSC) patients, especially those with homologous recombination (HR)-deficient tumors. However, new treatment strategies, such as immune checkpo...

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Detalles Bibliográficos
Autores principales: Matsushita, Hirokazu, Hasegawa, Kosei, Oda, Katsutoshi, Yamamoto, Shogo, Asada, Kayo, Karasaki, Takahiro, Yabuno, Akira, Nishijima, Akira, Nejo, Takahide, Kobayashi, Yukari, Sato, Sho, Ikeda, Yuji, Miyai, Manami, Takahashi, Yusuke, Yamaguchi, Rui, Fujiwara, Keiichi, Aburatani, Hiroyuki, Kakimi, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254153/
https://www.ncbi.nlm.nih.gov/pubmed/32461346
http://dx.doi.org/10.1136/jitc-2019-000375

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