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High expression of VCAN is an independent predictor of poor prognosis in gastric cancer

OBJECTIVE: Versican (VCAN) has been reported as a potential biomarker in some cancers. However, its role in gastric cancer (GC) is poorly understood. METHODS: Associations between clinical variables and VCAN were assessed. The diagnostic value of VCAN expression in GC patients was determined through...

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Detalles Bibliográficos
Autores principales: Li, Wenfei, Han, Fang, Fu, Min, Wang, Zhanqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254169/
https://www.ncbi.nlm.nih.gov/pubmed/31939331
http://dx.doi.org/10.1177/0300060519891271
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author Li, Wenfei
Han, Fang
Fu, Min
Wang, Zhanqiu
author_facet Li, Wenfei
Han, Fang
Fu, Min
Wang, Zhanqiu
author_sort Li, Wenfei
collection PubMed
description OBJECTIVE: Versican (VCAN) has been reported as a potential biomarker in some cancers. However, its role in gastric cancer (GC) is poorly understood. METHODS: Associations between clinical variables and VCAN were assessed. The diagnostic value of VCAN expression in GC patients was determined through receiver operating characteristic (ROC) curve analysis. Cox regression and the Kaplan–Meier method were used to explore clinicopathologic factors related to overall survival in GC patients. The Gene Expression Omnibus and the Human Protein Atlas were used for further validation. Gene set enrichment analysis (GSEA) was performed using The Cancer Genome Atlas dataset. RESULTS: High expression of VCAN was associated with high stage and T classification in GC. The area under the ROC curve was 0.853. Patients with high VCAN expression had worse prognoses than those with low VCAN expression. Multivariate analysis showed that VCAN was an independent risk factor for overall survival in both cohorts. GSEA identified pathways involved in cancer, ECM-receptor interaction, Wnt signaling, T cell receptor signaling, and chemokine signaling as differentially enriched in GCs with high VCAN expression. CONCLUSION: We demonstrated that VCAN is expressed at high levels in GC, and represents a potential independent molecular marker for diagnosis and prognosis of GC.
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spelling pubmed-72541692020-06-08 High expression of VCAN is an independent predictor of poor prognosis in gastric cancer Li, Wenfei Han, Fang Fu, Min Wang, Zhanqiu J Int Med Res Retrospective Clinical Research Report OBJECTIVE: Versican (VCAN) has been reported as a potential biomarker in some cancers. However, its role in gastric cancer (GC) is poorly understood. METHODS: Associations between clinical variables and VCAN were assessed. The diagnostic value of VCAN expression in GC patients was determined through receiver operating characteristic (ROC) curve analysis. Cox regression and the Kaplan–Meier method were used to explore clinicopathologic factors related to overall survival in GC patients. The Gene Expression Omnibus and the Human Protein Atlas were used for further validation. Gene set enrichment analysis (GSEA) was performed using The Cancer Genome Atlas dataset. RESULTS: High expression of VCAN was associated with high stage and T classification in GC. The area under the ROC curve was 0.853. Patients with high VCAN expression had worse prognoses than those with low VCAN expression. Multivariate analysis showed that VCAN was an independent risk factor for overall survival in both cohorts. GSEA identified pathways involved in cancer, ECM-receptor interaction, Wnt signaling, T cell receptor signaling, and chemokine signaling as differentially enriched in GCs with high VCAN expression. CONCLUSION: We demonstrated that VCAN is expressed at high levels in GC, and represents a potential independent molecular marker for diagnosis and prognosis of GC. SAGE Publications 2020-01-15 /pmc/articles/PMC7254169/ /pubmed/31939331 http://dx.doi.org/10.1177/0300060519891271 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Li, Wenfei
Han, Fang
Fu, Min
Wang, Zhanqiu
High expression of VCAN is an independent predictor of poor prognosis in gastric cancer
title High expression of VCAN is an independent predictor of poor prognosis in gastric cancer
title_full High expression of VCAN is an independent predictor of poor prognosis in gastric cancer
title_fullStr High expression of VCAN is an independent predictor of poor prognosis in gastric cancer
title_full_unstemmed High expression of VCAN is an independent predictor of poor prognosis in gastric cancer
title_short High expression of VCAN is an independent predictor of poor prognosis in gastric cancer
title_sort high expression of vcan is an independent predictor of poor prognosis in gastric cancer
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254169/
https://www.ncbi.nlm.nih.gov/pubmed/31939331
http://dx.doi.org/10.1177/0300060519891271
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