NADPH and Glutathione Redox Link TCA Cycle Activity to Endoplasmic Reticulum Homeostasis

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Many metabolic diseases disrupt endoplasmic reticulum (ER) homeostasis, but little is known about how metabolic activity is communicated to the ER. Here, we show in hepatocytes and other metabolically active cells that decreasing the availability of substrate for the tricarboxylic acid (TCA) cycle d...

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Detalles Bibliográficos
Autores principales: Gansemer, Erica R., McCommis, Kyle S., Martino, Michael, King-McAlpin, Abdul Qaadir, Potthoff, Matthew J., Finck, Brian N., Taylor, Eric B., Rutkowski, D. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254477/
https://www.ncbi.nlm.nih.gov/pubmed/32417402
http://dx.doi.org/10.1016/j.isci.2020.101116
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