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Glanzmann’s thrombasthenia with spontaneous upper gastrointestinal bleeding: a case report

Glanzmann’s thrombasthenia (GT) is a rare bleeding disorder inherited in an autosomal recessive manner. The pathogenesis of GT mainly involves structural abnormalities and dysfunction of platelet membrane glycoprotein IIb/IIIa (integrin αIIbβ3). The most common symptoms of GT are various types of bl...

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Autores principales: Qiao, Zhenguo, Chen, Yi, Shi, Wangtianyi, Yang, Jun, Song, Yi, Shen, Jiaqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254599/
https://www.ncbi.nlm.nih.gov/pubmed/32212884
http://dx.doi.org/10.1177/0300060520904849
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author Qiao, Zhenguo
Chen, Yi
Shi, Wangtianyi
Yang, Jun
Song, Yi
Shen, Jiaqing
author_facet Qiao, Zhenguo
Chen, Yi
Shi, Wangtianyi
Yang, Jun
Song, Yi
Shen, Jiaqing
author_sort Qiao, Zhenguo
collection PubMed
description Glanzmann’s thrombasthenia (GT) is a rare bleeding disorder inherited in an autosomal recessive manner. The pathogenesis of GT mainly involves structural abnormalities and dysfunction of platelet membrane glycoprotein IIb/IIIa (integrin αIIbβ3). The most common symptoms of GT are various types of bleeding, including recurrent nasal bleeding, mucocutaneous bleeding, unremitting bleeding after injury or operation, and menorrhea in women. Such hemorrhage may be fatal in some patients. GT with spontaneous upper gastrointestinal bleeding is relatively rare. In the present report, we describe a middle-aged man who was hospitalized with spontaneous upper gastrointestinal bleeding. His main symptom was recurrent chronic and intermittent melena. Gastroscopy revealed oozing of blood in the gastric antrum wall. However, no obvious lesions such as erosion or ulceration were found. Upon further inspection, we found that the patient’s platelet aggregation was poor, and flow cytometry assay revealed low expression of platelet membrane integrin αIIbβ3. The patient was eventually diagnosed with GT and exhibited clinical improvement after active treatment.
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spelling pubmed-72545992020-06-08 Glanzmann’s thrombasthenia with spontaneous upper gastrointestinal bleeding: a case report Qiao, Zhenguo Chen, Yi Shi, Wangtianyi Yang, Jun Song, Yi Shen, Jiaqing J Int Med Res Case Report Glanzmann’s thrombasthenia (GT) is a rare bleeding disorder inherited in an autosomal recessive manner. The pathogenesis of GT mainly involves structural abnormalities and dysfunction of platelet membrane glycoprotein IIb/IIIa (integrin αIIbβ3). The most common symptoms of GT are various types of bleeding, including recurrent nasal bleeding, mucocutaneous bleeding, unremitting bleeding after injury or operation, and menorrhea in women. Such hemorrhage may be fatal in some patients. GT with spontaneous upper gastrointestinal bleeding is relatively rare. In the present report, we describe a middle-aged man who was hospitalized with spontaneous upper gastrointestinal bleeding. His main symptom was recurrent chronic and intermittent melena. Gastroscopy revealed oozing of blood in the gastric antrum wall. However, no obvious lesions such as erosion or ulceration were found. Upon further inspection, we found that the patient’s platelet aggregation was poor, and flow cytometry assay revealed low expression of platelet membrane integrin αIIbβ3. The patient was eventually diagnosed with GT and exhibited clinical improvement after active treatment. SAGE Publications 2020-03-25 /pmc/articles/PMC7254599/ /pubmed/32212884 http://dx.doi.org/10.1177/0300060520904849 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Qiao, Zhenguo
Chen, Yi
Shi, Wangtianyi
Yang, Jun
Song, Yi
Shen, Jiaqing
Glanzmann’s thrombasthenia with spontaneous upper gastrointestinal bleeding: a case report
title Glanzmann’s thrombasthenia with spontaneous upper gastrointestinal bleeding: a case report
title_full Glanzmann’s thrombasthenia with spontaneous upper gastrointestinal bleeding: a case report
title_fullStr Glanzmann’s thrombasthenia with spontaneous upper gastrointestinal bleeding: a case report
title_full_unstemmed Glanzmann’s thrombasthenia with spontaneous upper gastrointestinal bleeding: a case report
title_short Glanzmann’s thrombasthenia with spontaneous upper gastrointestinal bleeding: a case report
title_sort glanzmann’s thrombasthenia with spontaneous upper gastrointestinal bleeding: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254599/
https://www.ncbi.nlm.nih.gov/pubmed/32212884
http://dx.doi.org/10.1177/0300060520904849
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